uterine leiomyoma


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leiomyoma

 [li″o-mi-o´mah]
a benign tumor derived from smooth muscle, most often of the uterus (leiomyoma uteri).
bizarre leiomyoma epithelioid leiomyoma.
leiomyoma cu´tis one arising from cutaneous or subcutaneous smooth muscle fibers, found singly or multiply, usually as lesions arising from arrectores pilorum muscles; it may also occur as a solitary genital lesion or a solitary angioleiomyoma arising from the muscle of veins.
epithelioid leiomyoma one in which the cells are polygonal rather than spindle shaped, usually found in the stomach. Called also bizarre leiomyoma and leiomyofibroma.
leiomyoma u´teri (uterine leiomyoma) leiomyoma of the uterus; called also uterine myoma and, colloquially, fibroids. It is the most common of all tumors found in women. It may occur in any part of the uterus, although it is most frequently in the body of the organ.

Leiomyomas usually occur during the third and fourth decades, and are often multiple, although a single tumor may occur. They are usually small but may grow quite large and occupy most of the uterine wall; after menopause, growth usually ceases. Symptoms vary according to the location and size of the tumors. As they grow they may cause pressure on neighboring organs, painful menstruation, profuse and irregular menstrual bleeding, vaginal discharge, or frequent urination, as well as enlargement of the uterus.

In pregnancy, the tumors may interfere with natural enlargement of the uterus with the growing fetus. They may also cause spontaneous abortion and death of the fetus.

Small leiomyomas are usually left undisturbed and are checked at frequent intervals. Larger tumors may be removed surgically, sometimes accompanied by a hysterectomy, or medication may be prescribed to induce a temporary menopause.
Leiomyoma of the uterus. The tumors may be subserosal, intramural, or submucosal. Subserosal and submucosal tumors may be pedunculated and may protrude from the uterine surface or into the uterine cavity, respectively. The stalk of pedunculated tumors may also become twisted. From Damjanov, 2000.

uterine leiomyoma

A leiomyoma of the uterus. It is the most common tumor of the female reproductive tract.

Symptoms

Leiomyomas may sometimes cause abdominal or pelvic heaviness, abnormal uterine bleeding, frequent urination, dysparunia, or pain.

Leiomyomas are classified according to their location. Subserous leiomyomas are found in the peritoneal covering of the uterus. They may be large or small, firm protuberances from the outer surface of the uterus or be attached by pedicles. Intraligamentous leiomyomas are found in the broad ligament. They may have uterine attachment. Intramural leiomyomas are found in the muscle wall of the uterus. If large, they can give the uterus a nodular, irregular shape. Submucosal leiomyomas are found next to the endometrium. Their most common symptoms are excessive, often abnormal bleeding, abdominal cramping, or pain. Cervical leiomyomas may cause stress incontinence, polyuria, dysparunia, or increased vaginal discharge.

Treatment

These tumors grow only during the reproductive years, often regressing after menopause. Surgical treatment (myomectomy or hysterectomy) may be necessary if tumors are more than 20 weeks' gestational size. Some tumors may be removed laproscopically although submucous tumors are removed by dilatation and curettage (D& C) or by hysteroscopy. Gonadotrophin-releasing hormones (GnRH) cause suppression of ovarian hormones and may cause tumors to shrink. Synonym: fibroid tumor; fibroid of uterus; fibromyoma (2); myoma uteri; uterine fibroma

See also: leiomyoma
References in periodicals archive ?
ER-[beta] rs1271572 G/T polymorphism: The frequencies of genotype GG, GT and TT were 0% 77.3% and 22.7% in controls and 0%, 19.3% and 80.7% in patients with uterine leiomyoma, respectively.
Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation.
Entropy of T2-weighted imaging combined with apparent diffusion coefficient in prediction of uterine leiomyoma volume response after uterine artery embolization.
Chromosome analysis of 96 uterine leiomyomas. Cancer Genet Cytogenet 1991; 55:11-8.
Uterine leiomyomas are highly common lesions of unclear etiology.
The natural history of uterine leiomyomas: light and electron microscopic studies of fibroid phases, interstitial ischemia, inanosis, and reclamation.
Taboas et al., "Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma," Matrix Biology, vol.
CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.
This patient had undergone no previous surgical procedures, caesarean section, laparotomy or laparoscopy and had no history of uterine leiomyomas. The tumor grows in pregnancy due to maternal hormonal effect and this typically occurred in this patient.
Intravenous leiomyomatosis with uterine leiomyoma and adenomyosis: a case presentation and brief comment on the histogenesis.
[USPRwire, Mon Oct 05 2015] Global Markets Direct's, 'Uterine Leiomyoma (Uterine Fibroids) - Pipeline Review, H2 2015', provides an overview of the Uterine Leiomyoma (Uterine Fibroids)'s therapeutic pipeline.
Both lesions were similar to uterine leiomyoma. However, RCC has similar MRI features and it was not possible to rule out malignancy.