Usual interstitial pneumonia
in rheumatoid arthritis-associated interstitial lung disease.
The 2011 official American Thoracic Society and European Respiratory Society (ATS/ERS) statement on the diagnosis and treatment of idiopathic pulmonary fibrosis (IPF), among other recommendations, recognized that a histopathologic confirmation was not needed in patients with idiopathic ILD who had a usual interstitial pneumonia
(UIP) pattern on HRCT of the chest.
The 190-gene Envisia classifier detects the genomic pattern of usual interstitial pneumonia
, a hallmark of IPF, with high accuracy (88% specificity and 70% sensitivity).
A HRCT scan was performed, and all the three IPF patients were consistent with a definitive usual interstitial pneumonia
(UIP) pattern on HRCT (which is updated as 'typical UIP' according to the Fleischner Society White Paper), including the presence of bilateral, predominantly subpleural, basal reticular abnormalities, traction bronchiectasis, and honeycombing and the absence of additional features considered incompatible with a diagnosis of IPF.
[1,2] The pathological correlate is usual interstitial pneumonia
Xu et al., "Nonspecific interstitial pneumonia and usual interstitial pneumonia
: comparison of the clinicopathologic features and prognosis," Journal of Thoracic Disease, vol.
Ferrans, "Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia
and desquamative interstitial pneumonia," The American Journal of Surgical Pathology, vol.
PLCH shares it cystic pathogenesis with usual interstitial pneumonia
which is distinguished by clustered distribution of its cysts preponderant in the lower lung zones .
If the high resolution CT (HRCT) scan is typical for a usual interstitial pneumonia
(UIP), no biopsy of any kind is indicated to confirm a UIP pattern .
Baga et al., "Nonspecific interstitial pneumonia and usual interstitial pneumonia
with mutation in surfactant protein C in familial pulmonary fibrosis," Modern Pathology: An Official Journal of The United States And Canadian Academy of Pathology, vol.
High-resolution computed tomography features of nonspecific interstitial pneumonia and usual interstitial pneumonia
. J Comput Assist Tomogr.
IPF is characterized by variable degrees of inflammation and scarring and is associated with a histologic or radiologic pattern of usual interstitial pneumonia