ursodiol


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ursodiol

 [ur″so-di´ol]
the secondary bile acid ursodeoxycholic acid used as an anticholelithic to dissolve radiolucent, noncalcified gallstones.

ur·so·di·ol

(ŭr'sō-dī'ōl),
A bile acid used to facilitate the dissolution of gallstones in patients; a potential alternative to cholecystectomy.

ursodiol

Actigall®, ursodeoxycholic acid Hepatology A pharmacologic preparation of ursodeoxylcholic acid, a 2º bile acid, used to dissolve bile gallstones and manage primary biliary cirrhosis. See Primary biliary cirrhosis.

ur·so·di·ol

(ŭr'sō-dī'ōl)
A bile acid used to facilitate the dissolution of gallstones in patients; a potential alternative to cholecystectomy.
Synonym(s): ursodeoxycholic acid.
References in periodicals archive ?
The company will be reporting the results of a subset of patients with compensated cirrhosis from an ongoing Phase 2 study designed to assess the safety and efficacy of seladelpar at a daily dose of 5 mg or 10 mg in PBC patients who had an inadequate response or an intolerance to ursodiol and a total bilirubin.
Epic is on target to have the solid oral dose products with serialization-ready labels by November 2018, and as of this month began distribution of the first two serialized products, ursodiol capsules, 300 mg, and demeclocycline HC1 tablets, 150 mg and 300 mg.
But it actually contained no traces of ursodiol and had actually been made from pig gall bladders.
Group 2 was treated with UDCA (Ursodiol, 300 milligrams Capsule, Alborz Darou Pharmaceutical Co.) at a dosage of 15 mg/kg/day along with their routine chemotherapy drugs.
Cholecystectomy at time of bypass is not routinely performed because ursodiol use postoperatively reduces the incidence of gallstone formation [1, 2].
The patient completed a 10-day course of doxycycline but unfortunately suffered from bile cast nephropathy from severe hyperbilirubinemia with continued rise in Cr (Figure 1(a)), for which he was treated with cholestyramine and ursodiol. His liver function tests and kidney laboratory results began to improve thereafter, and he was discharged on hospital day 26.
She was treated with ursodiol and subsequently recovered.
Her baseline included diuretics, lactulose 10 ml TID, sodium benzoate 3g OD, metronidazole 250 mg BID, calcium carbonate 500 mg BID, and ursodiol 500 mg BID.
Obeticholic acid (Ocaliva) is a farnesoid X receptor agonist that is given orally for the treatment of primary biliary cholangitis, in combination with ursodiol, or ursodeoxycholic acid.
Ohkawa et al., "Ursodiol use is possibly associated with lower incidence of hepatocellular carcinoma in hepatitis C virus-associated liver cirrhosis," Cancer Epidemiology Biomarkers and Prevention, vol.
The patient was optimized on ursodiol with the addition of rifampin, cholestyramine, and diphenhydramine for worsening pruritus.
As the patient had been symptomatic for several months and her clinical status did not improve during a period of observation and trial of ursodiol, cholecystectomy was recommended.