Recent studies demonstrated that Urotensin II receptor predicts the clinical outcome of prostate cancer patients, so it is a helpful biomarker for PC3 recognition.
Campiglia et al., "A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge," Journal of Medicinal Chemistry, vol.
Amplification 756 bp means urotensin II receptor is knocked out and 63 bp means wild type; both 756 bp and 63 bp mean heterozygotes of UT gene knockout KO mouse as well as mRNA and protein expression of UT KO group, according to our previous publications .
Fujino, "Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain," Peptides, vol.
Cannavo et al., "EGFR transactivation by urotensin II receptor
is mediated by [beta]-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy," Basic Research in Cardiology, vol.
Urotensin II receptor (UT) is a Gq protein coupled receptor originally identified as the orphan GPR14 receptor by Ames et al.
Leduc, "Biological properties and functional determinants of the urotensin II receptor," Peptides, vol.
Hirai et al., "Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese," Peptides, vol.
Klabunde, "Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II," Journal of Medicinal Chemistry, vol.
Campiglia et al.," A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge," Journal of Medicinal Chemistry, vol.
Novellino, "Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists," Journal of Medicinal Chemistry, vol.
Binding with high affinity to a G-coupled protein receptor (GPR14, urotensin II receptor
) (3), UII is a potent vasoconstrictor of isolated vessels; exogenous UII administration to primates causes circulatory collapse via intense coronary artery vasoconstriction (3).