Greater decreases in albumin-creatinine ratio (ACR), interleukin-18, anti-chitinase-3-like protein 1 (YKL-40), and
uromodulin were seen in incident CKD participants in the intensive group versus matched control participants after one year of blood pressure intervention.
Multiple names have been proposed for this group of disorders, including medullary cystic kidney disease, familial juvenile hyperuricemic nephropathy, and
uromodulin associated kidney disease.
Similar reports revealed that THP may inhibit calcium oxalate crystal aggregation, whereas
uromodulin may promote aggregation [75].
Autosomal dominant tubulointerstitial kidney disease is a rare entity and is subclassified on a genetic basis that encompasses four mutations in the genes encoding
uromodulin (UMOD), hepatocyte nuclear factor 1-[beta] (HNF 1B), renin (REN), and mucin-1 (MUC-1) [4].
The signature included
uromodulin (UMOD), alpha-1-antitrypsin (A1AT) peptides, and beta-2-microglobulin (B2M) fragment.
The minor G allele of this SNP had an OR of 0.87 (95% CI: 0.84-0.91) for hypertension, with the subject having the minor G allele having decreased urinary
uromodulin and better renal function.
Mutation analysis of
uromodulin (UMOD) gene was performed using polymerase chain reaction (PCR) and direct sequencing.
When isolated from the urine of pregnant women the glycoprotein is called
uromodulin, but it has still the same amino acid sequence.
Uromodulin is a GPI-anchored glycoprotein and produced by the thick ascending limb of the loop of Henle of the mammalian kidney.
Bonet et al., "
Uromodulin and [alpha]1-antitrypsin urinary peptide analysis to differentiate glomerular kidney diseases," Kidney and Blood Pressure Research, vol.
They included fragments of alpha-1-anti trypsin (14 peptides), collagen alpha-1(I) and alpha-1(in) chains (6 peptides), and
uromodulin (7 peptides).
In addition to abovementioned peptide, the expression of
uromodulin, granulin, and proactivator peptide has been downregulated in FSGS subjects compared with healthy controls.
