urokinase

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Related to Urinary plasminogen activator: Plasminogen activator inhibitor

urokinase

 [u″ro-ki´nās]
u-plasminogen activator; the term is used particularly to denote a pharmaceutical preparation of the enzyme, administered intravenously as a thrombolytic agent in the treatment of acute coronary thrombosis and acute pulmonary embolism; also used to clear intravenous catheters of obstructions composed of clotted blood or fibrin deposits.

plas·min·o·gen ac·ti·va·tor

a proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former.
Synonym(s): urokinase

urokinase

/uro·ki·nase/ (UK) (u″ro-ki´nās) u-plasminogen activator; an enzyme in the urine of humans and other mammals, elaborated by the parenchymal cells of the human kidney and acting as a plasminogen activator. It is used as a therapeutic thrombolytic agent.

urokinase

(yo͝or′ō-kī′nās, -nāz)
n.
An enzyme originally found in human urine that catalyzes the conversion of plasminogen to plasmin and is used in medicine to dissolve blood clots.

urokinase

[yoo͡r′əkī′nās]
an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

Abbokinase

A proprietary formulation of urokinase, a thrombolytic that activates the fibrinolysis by increasing plasmin production from plasminogen, thereby degrading fibrin clots, fibrinogen, and other clotting factors.

urokinase

A fibrinolytic enzyme involved in extracellular proteolysis; it is more active during cell migration and tissue remodeling, and cleaves fibronectin. See Kringle domain. Cf Streptokinase, Reteplase, tPA.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase.

urokinase

An enzyme found in human urine that is used as a drug to dissolve blood clots occurring within blood vessels. A PLASMINOGEN activator.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase.

urokinase (yoor´ōkī´nās),

n an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

urokinase

an enzyme found in the urine of humans and other mammals which is secreted by kidney parenchymal cells and converts plasminogen to plasmin and activates the fibrinolytic system; used as a fibrinolytic agent.