of the expression of genes that are important to tumor growth and metastasis.
coli infection, the authors observed significant antibacterial response and upregulation
of genes involved in the innate immune response.
saRNAs have been demonstrated to activate transcription of specific genes resulting in upregulation
of proteins with therapeutic potential.
3] treatment with upregulation
of genes associated with skin barrier repair.
facility significantly enhances its research and manufacturing capabilities, expands its global commercial footprint, and advances its Duchenne muscular dystrophy (DMD) pipeline, which comprises an exon skipping platform and next generation approaches such as gene therapy and utrophin upregulation
We also found that IFN-[gamm]-stimulated spinal microglia show upregulation
of Lyn tyrosine kinase and purinergic P2X4 receptor.
Of those, 89 genes were demonstrated to be subject to significant upregulation
of mRNA in in vitro screening, and seven AntagoNAT oligonucleotides have been validated in vivo to date.
DC activation by sensitizers causes the upregulation
of costimulatory molecules such as CD86 (Linsley et al.
In the nucleus, [beta]-catenin interacts with the TCF/LEF transcription factors and, therefore, participates in the upregulation
or downregulation of some important genes involved in diverse cellular activities.
Isoprenaline (ISO, a [sz]-adrenergic agonist) has been reported to promote angiogenesis through upregulation
of vascular endothelial growth factor (VEGF) expression; however, the underlying mechanism remains to be investigated.
However, the data in the present meta-regression analysis raise the possibility that other interventions, especially those that ultimately act predominantly through upregulation
of LDL receptor expression, may provide additional options and may potentially be associated with the same relative clinical benefit per each 1 millimole per liter reduction in LDL-C.
rosea were listed, including effects on key mediators of stress response, regulation of homeostasis of hypothalamic-pituitary-adrenal axis activity, modulation of the G-protein coupled receptors and associated signalling pathways, upregulation
of neuropeptides, and other molecular networks involved in depression.