up-regulation

up-regulation

 [up reg-u-la´shun]
increase in expression of a gene; in the narrowest sense, that in which transcription of a specific mRNA is increased, but also used more broadly to refer to increase in mRNA levels for a particular gene from any cause, such as increased stability of the specific mRNA.
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As observed previously, the DerGPG70 conjugate modulated disease through up-regulation of Th2, and down-regulation of Th1 and Th17 responses.
Progressive retinal ischemia causes up-regulation of inflammatory mediators within the eye, leading to abnormal growth of blood vessels out of the retina and/or leakage, both of which cause vision loss and blindness if untreated.
The report continued: 'These findings are consistent with a selective up-regulation of innate immune responses to viral infections and provide insight into the immuno-regulatory correlates of one of the keystone experiences in human life.'
CD8B molecule contributes to CD8+ cell development (Bosselut et al., 2000), and CD81 protein is involved in activation, proliferation and differentiation of T cells (Levy et al., 1998), indicating that the 2 DEGs (CD8B down-regulation and CD81 up-regulation) may be associated with blood T lymphocyte subsets.
Besides, increased LVSCC activity leads to up-regulation of [Ca.sup.2+] related biomarkers in the aging hippocampus (5).
"An association has been demonstrated between chronic viral infection, malignancy, and up-regulation of programmed death receptor 1 (PD-1) on CD8+ cytotoxic T-lymphocytes," the authors wrote in Cancer Immunology Research.
Metadichol[R] treatment at different concentrations on Umbilical Cord which resulted in up-regulation of IRS1, IRS2, and GLUT4.
(5) On the other hand, the alteration of DNA methylation has been reported to be related to up-regulation of DNMTs and whole genome methyl analysis have shown hypomethylation and hypermethylation in pancreatic cancer.
Our lab is interested in the role of the endothelial fibronectin binding integrins because of their up-regulation in angiogenic vasculature.
Consistent with up-regulation of CEBPA, which has a role in myeloid differentiation, significant and repeated increases in neutrophils were observed after dosing MTL-CEBPA.
Down-regulation of Bcl-2 (an antiapoptotic protein), up-regulation of Bax (a pro-apoptotic protein), and activations of caspase-3 and -9 were found in TNF-[alpha] treated cells (P<0.01 or P<0.001, Figure 1D and E).
Expression of miR-100 showed up-regulation in 50(83.3%) subjects in the control group.