United Kingdom Prospective Diabetes Study


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United Kingdom Prospective Diabetes Study

; UKPDS multicentre, 20-year type 2 diabetes study published in 1998; demonstrated that 50% of type 2 diabetics present with some diabetes-related complications at diagnosis, 33% develop severe complications 9 years after initial diagnosis and death rates in type 2 diabetics are twice those of normal population; delineated that proactive health measures (tight glycaemic control; control of hypertension) reduce diabetes-related morbidity and mortality (e.g. stroke [×3], kidney damage [×13] and major eye disease [×14])
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In the 1990s, in the Diabetes Control and Complications Trial (DCCT) (3) and United Kingdom Prospective Diabetes Study (UKPDS) (4), an important question was answered: glycemic control does make a difference in the development of microvascular complications.
Elizabeth Koller, of CMS's Office of Clinical Standards and Quality, led off with a summary of the data from several prospective trials including the Diabetes Control and Complications Trial (DCCT) and the United Kingdom Prospective Diabetes Study (UKPDS), both considered benchmark studies in demonstrating the value of intensive glucose management for patients with diabetes.
Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23).
According to the landmark United Kingdom Prospective Diabetes Study (UKPDS), maintaining tight blood sugar control can significantly reduce diabetes-related complications.
The United Kingdom Prospective Diabetes Study was among the first to link reduced hemoglobin [A.
We used the United Kingdom Prospective Diabetes Study risk engine (www.
329[14]:977-86, 1993) and the United Kingdom Prospective Diabetes Study (Lancet 352[9131]:837-53, 1998) support this notion.
Prominent landmark studies - the United Kingdom Prospective Diabetes Study (UKPDS) and the Diabetes Complications and Control Trial (DCCT) - have shown this level to be associated with a reduced risk for microvascular complications (small blood vessel complications that result in eye, kidney and nerve damage) and macrovascular complications (which result in cardiovascular events such as heart attack and stroke).
The landmark United Kingdom Prospective Diabetes Study (UKPDS) revealed that tight blood sugar control may help delay or prevent the complications of type 2 diabetes.
Although the DCCT studied only those with type 1 diabetes, the United Kingdom Prospective Diabetes Study (UKPDS), completed in 1998, proved that the benefits of good blood glucose control also apply to those with type 2 diabetes, which involves insulin resistance -- the body's inability to properly use its own insulin.
Based on the United Kingdom Prospective Diabetes Study (UKPDS) showing that tight blood sugar control can delay or prevent the complications of type 2 diabetes, the American Diabetes Association has established an A1C level of no more than 7.
Because the United Kingdom Prospective Diabetes Study demonstrated that blood sugar control declines over time with older, traditional monotherapy, it's critical that we continue to search for therapeutic options that may provide sustained blood sugar control," said Martin Freed, M.

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