United Kingdom Prospective Diabetes Study


Also found in: Acronyms.

United Kingdom Prospective Diabetes Study

; UKPDS multicentre, 20-year type 2 diabetes study published in 1998; demonstrated that 50% of type 2 diabetics present with some diabetes-related complications at diagnosis, 33% develop severe complications 9 years after initial diagnosis and death rates in type 2 diabetics are twice those of normal population; delineated that proactive health measures (tight glycaemic control; control of hypertension) reduce diabetes-related morbidity and mortality (e.g. stroke [×3], kidney damage [×13] and major eye disease [×14])
Mentioned in ?
References in periodicals archive ?
In order to achieve glycemic target, more patients than at present will require combinations of oral agents and then, insulin therapy, according to the United Kingdom Prospective Diabetes Study (UKPDS), a pivotal 20-year study examining more than 5,000 patients with type 2 diabetes in 23 clinical centers in England, Northern Ireland and Scotland.
13 United Kingdom Prospective Diabetes Study (UKPDS) reported prevalence of 34% prevalence of DR in males and 35% in females in type 2 DM patients.
The United Kingdom Prospective Diabetes Study (UKPDS), which investigated newly diagnosed middle-aged patients with T2DM, revealed a reduction in cardiovascular events after 10 years in the group receiving intensive treatment.
Finally, the results of the ACCORD trial should also be compared with the 10-year follow-up of the approximately 10-year United Kingdom Prospective Diabetes Study (UKPDS) trial, which tested the effect of intensive glycemia management (during the active phase of the trial) in patients with newly diagnosed type 2 diabetes.
Data from two other studies presented at the congress showed that neither Framingham score nor the risk engine derived from the 1998 United Kingdom Prospective Diabetes Study (UKPDS) is an accurate risk predictor for patients receiving modern treatments for glucose, blood pressure, and lipid levels.
Metformin deserves the nod as the first-line agent on the basis of the results of the landmark United Kingdom Prospective Diabetes Study, which convincingly established the drug as the safest glucose-lowering agent available, she added.
A long term study (the United Kingdom Prospective Diabetes Study or UKPDS) published in September 1998 re-emphasized the fact that people with type 2 diabetes must make a concerted effort to keep blood glucose levels as close to normal as possible to delay or prevent the devastating complications associated with diabetes.
Results from the Diabetes Control and Complications Trial (DCCT) in patients with type 1 diabetes (1) and the United Kingdom Prospective Diabetes Study in patients with type 2 diabetes (2, 3) indicate that Hb [A.
26) The loss of [beta]-cell function is correlated with increasing A1C levels and disease progression, which was demonstrated in the United Kingdom Prospective Diabetes Study (UKPDS).
5) The United Kingdom Prospective Diabetes Study demonstrated that progressive [beta]-cell dysfunction results in loss of the prandial insulin response over time, and that only 50% of [beta]-cell function is present at the time of diagnosis.
Evidence from the Diabetes Control and Complications Trial (4) in the US, which involved type 1 diabetic patients, and from the United Kingdom Prospective Diabetes Study in the United Kingdom, which involved type 2 diabetic patients (5, 6), confirmed the long-held, but previously somewhat unsubstantiated, view that control of blood glucose was important in delaying the onset or preventing the development of complications.
The long-term efficacy of diet-based therapy was not sustained in the United Kingdom Prospective Diabetes Study (UKPDS) because observed weight loss and HbAlc improvements decreased over the course of the trial.

Full browser ?