UBC

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UBC

A gene on chromosome 12q24.3 that encodes ubiquitin C, which plays different roles depending on which lysine residue is covalently bound to what protein. Ubiquitins are either covalently attached to another protein, or free (unanchored). When covalently bound, ubiquitin is conjugated to target proteins, either as a monomer (monoubiquitin), a polymer linked to different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chain). Polyubiquitin chains attached to a target protein have different functions depending on the Lys residue of the ubiquitin attached. Linear polymer chains formed by attaching to the initiator Met lead to cell signalling. Free (unanchored) polyubiquitin is involved in activating protein kinases and in signalling.

UBC is also a less preferred gene symbol for what is now designated as UBB, see there.

Ubiquitin activities—Lys binding
• Lys-6-linked—DNA repair
• Lys-11-linked—ERAD (endoplasmic reticulum-associated degradation) and cell-cycle regulation.
• Lys-29-linked—Lysosomal degradation.
• Lys-33-linked—Kinase modification.
• Lys-48-linked—Protein degradation via proteasomes.
• Lys-63-linked—Endocytosis, DNA-damage responses, signalling and activation of transcription factor NF-kappaB.
References in periodicals archive ?
The Pakistan Building Code (Seismic Provisions 2007) is compatible with the Uniform Building Code 1997 (of USA) the American Concrete Institute ACI 31805 American Institute of Steel Construction ANSI/AISC 34105 American Society of Civil Engineers SEI/ASCE 705 and ANSI/ASCE 793.
While the 1997 Uniform Building Code (UBC) is the general seismic touchstone by which all buildings in Dubai have been constructed over the last decade and a half, questions do, however, still remain over those which predate its introduction.
Codes selected for this study includes Uniform Building Code 1997(UBC), Euro code 2005 (EC-05), Turkish Code 1998 (TK-98) and National Building code of India 2005(NBCI-05) along with building code of Pakistan 2007 (BCP-07).
The classes, which cover project management and the state's uniform building code, would form the basis of a two-year associate's degree program designed to feed into California State University, Fresno's, bachelor's degree program in construction management.
Up until now, the trades only had the electrical code or Uniform Building Code and those types of references," Dal Pino said.
The IRC works in tandem with the Uniform Building Code (UBC), which regulates commercial building, explains Ron Burton, an assistant vice president in the division of the NAHB that monitors construction, codes, and standards.
While supporting building-code organizations' recent efforts to incorporate the accessibility guidelines into a uniform building code, Bollinger rejected the notion that disputes over interpretations of the accessibility guidelines should be used to absolve those who chose to ignore fair-housing accessibility requirements over the past eight years.
The latest editions of all three model codes (1996 BOCA National Building Code, 1997 ICBO Uniform Building Code, and 1997 SBCCI Standard Building Code) have provisions designed to meet the federal accessibility requirements.
Both have also issued experimental permits for load-bearing straw residential structure under sections 105 and 1076 of the Uniform Building Code (UBC) which allows for experimental construction using alternative methods and materials.
The 1994 Uniform Building Code calls for mechanical smoke controls, but the 1994 Life Safety Code and the 1993 National Building Code do not mandate such systems in high-rise buildings protected by sprinklers.
REBNY's Board Services will have copies of this local law, as well as the text of the section of the Uniform Building Code which it modifies, available after March 28 at the cost of $12 plus $2.
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