UBC

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UBC

A gene on chromosome 12q24.3 that encodes ubiquitin C, which plays different roles depending on which lysine residue is covalently bound to what protein. Ubiquitins are either covalently attached to another protein, or free (unanchored). When covalently bound, ubiquitin is conjugated to target proteins, either as a monomer (monoubiquitin), a polymer linked to different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chain). Polyubiquitin chains attached to a target protein have different functions depending on the Lys residue of the ubiquitin attached. Linear polymer chains formed by attaching to the initiator Met lead to cell signalling. Free (unanchored) polyubiquitin is involved in activating protein kinases and in signalling.

UBC is also a less preferred gene symbol for what is now designated as UBB, see there.

Ubiquitin activities—Lys binding
• Lys-6-linked—DNA repair
• Lys-11-linked—ERAD (endoplasmic reticulum-associated degradation) and cell-cycle regulation.
• Lys-29-linked—Lysosomal degradation.
• Lys-33-linked—Kinase modification.
• Lys-48-linked—Protein degradation via proteasomes.
• Lys-63-linked—Endocytosis, DNA-damage responses, signalling and activation of transcription factor NF-kappaB.
References in periodicals archive ?
There are three main code bodies in the United States: the Uniform Building Code (UBC), covering most states west of the Mississippi; the National Building Code (NBC), adhered to by most states in the Northeast and New England areas; and the Standard Building Code (SBC), covering most states in the Deep South.
The Uniform Building Code and the Uniform Mechanical Code set the dimensions and locations for roof vents.
The New York City Seismic Code is a revised version of the 1990 Uniform Building Code (UBC), already followed for all federal projects.
The structure can withstand almost any kind of weather, and meets -- or exceeds -- Uniform Building Code requirements for permanent houses.
The Pakistan Building Code (Seismic Provisions 2007) is compatible with the Uniform Building Code 1997 (of USA) the American Concrete Institute ACI 31805 American Institute of Steel Construction ANSI/AISC 34105 American Society of Civil Engineers SEI/ASCE 705 and ANSI/ASCE 793.
While the 1997 Uniform Building Code (UBC) is the general seismic touchstone by which all buildings in Dubai have been constructed over the last decade and a half, questions do, however, still remain over those which predate its introduction.
There are four main codes which have been selected for the critical review of RBM which are Uniform Building code 1997 abbreviated as (UBC-97), European Code 2005 abbreviated as (EC-05), Turkish Code 1998 abbreviated as (TC-98) and National Building code of India2005 abbreviated as (NBCI-05).
"Up until now, the trades only had the electrical code or Uniform Building Code and those types of references," Dal Pino said.
The enclosures meet the Uniform Building Code seismic zone 4 upper floor requirements, for protecting 1,000 pounds of essential equipment.
The IRC works in tandem with the Uniform Building Code (UBC), which regulates commercial building, explains Ron Burton, an assistant vice president in the division of the NAHB that monitors construction, codes, and standards.
When putting fireplaces and wood-burning stoves into place, the Uniform Building Code states that a smokestack, or single wall flue, must be kept 18 inches away from any combustible surfaces.
The Uniform Building Code (UBC) 1994 edition, Section 713.7, does not allow a glazed opening in a door with a three-hour fire-resistance rating.
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