2] Others have postulated that there might be a fibroblastic, histiocystic, or undifferentiated mesenchymal cell
Under certain conditions, BMPs can also induce the transformation of undifferentiated mesenchymal cells
into bone cells and induce the proliferation of bone cells, indicating that they are one of the most important factors in osteogenesis (14,15).
These undifferentiated mesenchymal cells
are capable of fibroblastic differentiation also.
The elaboration of this antigen suggests a vascular endothelial origin or induction of vascular structure formation by undifferentiated mesenchymal cells
Based on these findings, we speculate that BMP2 overexpression in adrenal ML cases is closely related to an aberrant canonical Wnt/[beta]-catenin signaling pathway, while BMP2 induction by the tumour cells may affect ectopic bone formation by transforming undifferentiated mesenchymal cells
into osteoblast-like cells.
Those lesions that do develop are believed to arise from the tunica media or from pluripotential undifferentiated mesenchymal cells