UCP3

(redirected from Uncoupling protein-3)

UCP3

A gene on chromosome 11q13.4 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCP3 is expressed primarily in skeletal muscle, and thought to protect mitochondria against lipid-induced oxidative stress.
References in periodicals archive ?
Villarroya, "Functional relationship between myod and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription," Molecular Endocrinology, vol.
Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export.
Effect of heat exposure on uncoupling protein-3 mRNA abundance in porcine skeletal muscle.
Sequencing analysis on partial translated region of uncoupling protein-3 gene and single nucleotide polymorphism associations with the porcine carcass and meat quality traits.
Harper, "Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export," The Journal of Biological Chemistry, vol.
Uncoupling protein-3 (UCP3) mRNA expression in reconstituted human muscle after myoblast transplantation in RAG2-/-/gamma c/C5(-) immunodeficient mice.
Bo et al., "Upregulation of uncoupling protein-3 in skeletal muscle during exercise: a potential antioxidant function," Free Radical Biology and Medicine, vol.
Dois dos pesquisadores realizaram busca booleana de forma independente com os seguintes descritores: exercicio, UCP-3, termogenese, exercise, uncoupling protein, uncoupling protein-3 e themogenesis; foram separados os trabalhos conduzidos de forma controlada e randomizada, tanto em modelo animal quanto em seres humanos.