UCP3

(redirected from Uncoupling protein-3)

UCP3

A gene on chromosome 11q13.4 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCP3 is expressed primarily in skeletal muscle, and thought to protect mitochondria against lipid-induced oxidative stress.
References in periodicals archive ?
Interestingly, additional evidence suggests a role of UPS not only in controlling the outer membrane protein quality but also in the regulation of the proteome of other mitochondrial compartments, such as the matrix [oligomycin sensitivity-conferring protein (OSCP), component of the mitochondrial membrane ATP synthase], the intramembrane space (Endonuclease G), and the inner membrane [Uncoupling Protein-2 and Uncoupling Protein-3 (UCP2 and UCP3)] [139-141].
Dois dos pesquisadores realizaram busca booleana de forma independente com os seguintes descritores: exercicio, UCP-3, termogenese, exercise, uncoupling protein, uncoupling protein-3 e themogenesis; foram separados os trabalhos conduzidos de forma controlada e randomizada, tanto em modelo animal quanto em seres humanos.
Upregulation of uncoupling protein-3 in skeletal muscle during exercise: a potential antioxidant function," Free Radical Biology and Medicine, vol.
Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-a in the control of mouse uncoupling protein-3 gene expression," Endocrinology, vol.
Villarroya, "Functional relationship between myod and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription," Molecular Endocrinology, vol.