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A protein found in brown adipose tissue that acts as a thermogenic uncoupling protein of oxidative phosphorylation; it allows thermogenesis in this type of tissue.


A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.


a thermogenic protein involved in the lipolysis of brown adipose tissue.
References in periodicals archive ?
Seasonal regulations of energetics, serum concentrations of leptin, and uncoupling protein 1 content of brown adipose tissue in root voles (Microtus oeconomus) from the Qinghai-Tibetan plateau.
Cloning and ontogenetic expression of the uncoupling protein 1 gene UCP1 in sheep.
The general consensus is that cold stimulates a greater release of catecholamines by the nervous system, an event that stimulates thermogenesis through the activation of protein kinase A (PKA) and p38 mitogen-activated protein kinases (p-38 MAPK) pathways followed by the activation of uncoupling protein 1 (UCP1) and phosphorylation of the specific factors PPAR gamma coactivator 1 alpha (PGC-1[alpha]), cAMP response element-binding protein (cReB), and activating transcription factor 2 (ATF2) [14,15, 44, 45].
Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage," Circulation, vol.
In contrast, thermogenic adipose tissue defends against hypothermia and obesity through adaptive thermogenesis mediated by the regulated expression and activity of mitochondrial uncoupling protein 1 (UCP1).
Identification of a Functioning Mitochondrial Uncoupling Protein 1 in Thymus.
Nanomolar levels of this protein increase uncoupling protein 1 (UCP1) in cultures of primary white fat cells by 50 fold or more, resulting in very large increases in uncoupled respiration.
Fucoxanthin facilitates youthful energy meta-bolism by activating a special cellular protein called mitochondrial uncoupling protein 1 (or UCP1).
A group of Japanese marine biologists11 discovered during their research that when study animals were supplemented with fucoxanthin, something unexpected occurred--mitochondrial uncoupling protein 1 (UCP1) was expressed in white adipose (fat) tissue.
Collins, "[beta]-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase," The Journal of Biological Chemistry, vol.
After a 7-week acclimation, we determined body mass, energy inatke, resting metabolic rate (RMR), nonshivering thermogenesis (NST), digestive tract morphology, serum leptin level, triiodothyronine (T3), thyroxine (T4) concentrations, mitChondrial protein content (MP), cytChrome c oxidase (COX) activity in liver and brown adipose tissue (BAT), and uncoupling protein 1 (UCP1) content in BAT.
Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression.