(redirected from Uncoupling protein 1)


A protein found in brown adipose tissue that acts as a thermogenic uncoupling protein of oxidative phosphorylation; it allows thermogenesis in this type of tissue.


A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.


a thermogenic protein involved in the lipolysis of brown adipose tissue.
References in periodicals archive ?
Nanomolar levels of this protein increase uncoupling protein 1 (UCP1) in cultures of primary white fat cells by 50 fold or more, resulting in very large increases in uncoupled respiration.
Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression.
Fucoxanthin facilitates youthful energy meta-bolism by activating a special cellular protein called mitochondrial uncoupling protein 1 (or UCP1).
A group of Japanese marine biologists11 discovered during their research that when study animals were supplemented with fucoxanthin, something unexpected occurred--mitochondrial uncoupling protein 1 (UCP1) was expressed in white adipose (fat) tissue.