thermogenin(redirected from Uncoupling protein 1)
A protein found in brown adipose tissue that acts as a thermogenic uncoupling protein of oxidative phosphorylation; it allows thermogenesis in this type of tissue.
UCP1A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.
a thermogenic protein involved in the lipolysis of brown adipose tissue.