UCP3

(redirected from Uncoupling Protein 3)
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UCP3

A gene on chromosome 11q13.4 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCP3 is expressed primarily in skeletal muscle, and thought to protect mitochondria against lipid-induced oxidative stress.
References in periodicals archive ?
Reitman, "Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes," Biochemical and Biophysical Research Communications, vol.
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.
Regulation of the expression of the avian uncoupling protein 3 by isoproterenol and fatty acids in chick myoblasts: possible involvement of AMPK and PPARalpha?
Russell III, "Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning," American Journal of Physiology--Heart and Circulatory Physiology, vol.
Sannino et al., "Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure," Journal of the American Heart Association, vol.
Zheng et al., "Uncoupling protein 3 mediates [H.sub.2][O.sub.2] preconditioning-afforded cardioprotection through the inhibition of MPTP opening," Cardiovascular Research, vol.
Harper, "Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells," Diabetes, vol.