UCP2

(redirected from Uncoupling Protein 2)
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UCP2

A gene on chromosome 11q13 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP2 is expressed in many tissues, especially in skeletal muscle, and thought to play a role in thermogenesis, obesity and diabetes.
References in periodicals archive ?
Transgenic overexpression of uncoupling protein 2 attenuates salt-induced vascular dysfunction by inhibition of oxidative stress," American Journal of Hypertension, vol.
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.
Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation.
The association between the Val/Ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency.
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
A common polymorphism of uncoupling protein 2 gene is associated with hypertension.
Chou, "Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching," Nature, vol.
Brand, "Superoxide activates mitochondrial uncoupling protein 2 from the matrix side.
Inhibition of uncoupling protein 2 attenuates cardiac hypertrophy induced by transverse aortic constriction in mice," Cellular Physiology and Biochemistry, vol.
Van Bilsen, "Effects of fatty acids on uncoupling protein 2 expression in the rat heart," The FASEB Journal, vol.