UCP2

(redirected from Uncoupling Protein 2)
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UCP2

A gene on chromosome 11q13 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP2 is expressed in many tissues, especially in skeletal muscle, and thought to play a role in thermogenesis, obesity and diabetes.
References in periodicals archive ?
Crispim, "The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications," Arquivos Brasileiros de Endocrinologia e Metabologia, vol.
In addition, the researchers verified that the hypocretin neurons producing uncoupling protein 2 were not involved in temperature regulation.
The association between the Val/Ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency.
Current studies show that the mechanisms by which steatotic livers are more susceptible are related to an increased sensitivity to endotoxin and high levels of uncoupling protein 2 at baseline.
The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling protein 3 and metabolic data in dogs.
Among the 451 proteins, several oxidative stress-related proteins such as aconitase, glutathione peroxidase, uncoupling protein 2, peroxidase, and manganese superoxide dismutase, were affected.
For example, miR-30e inhibited TGF-[sz][sub]1-induced ECM production in TECs by targeting mitochondrial uncoupling protein 2 , [sup][29] whereas miR-34a promoted kidney fibrosis by targeting Notch 1 and Jagged 1 in hypoxia-induced renal TECs.[sup][30]
Within the mitochondria, uncoupling protein 2 (UCP2) has recentlybeen reported as a negative regulator of ROS generation [65].
The variations modulate production of a molecule called uncoupling protein 2 (UCP2), which converts calories into heat instead of fat.
Horvath, "Mitochondrial uncoupling protein 2 (UCP2) regulates retinal ganglion cell number and survival," Journal of Molecular Neuroscience, vol.
The gene, described in the March Nature Genetics, encodes a molecule that researchers have dubbed uncoupling protein 2, or UCP2.
Shibusawa et al., "Genomic organization and promoter function of the mouse uncoupling protein 2 (UCP2) gene," FEBS Letters, vol.