found that unconjugated bilirubin
mediated heme oxygenase-1-induced vascular benefits which suggested bilirubin as a potential therapeutic target for clinical intervention of diabetic vasculopathy.
Abbreviations ALT: Alanine aminotransferase AST: Aspartate aminotransferase BUN: Blood urea nitrogen Cr: Creatinine CCR: Creatinine clearance rate DB: Conjugated bilirubin GFR: Glomerular filtration rate Hb: Hemoglobin TB: Total bilirubin IB: Unconjugated bilirubin
At birth the child was admitted to the Intensive Care Unit for neonatal immaturity and respiratory distress, and she was diagnosed with hereditary stomatocytosis associated with beta-thalassemia trait (Hb 10.6 g/dL, MCV 71.9 fL, stomatocytes 22%, reticulocytes 260 x [10.sup.9]/L, and unconjugated bilirubin
Dioguardi, "Acute ethanol administration increases biliary concentrations of total and unconjugated bilirubin
in rabbits," Digestive Diseases and Sciences, vol.
Kernicterus is a preventable condition; the unconjugated bilirubin
levels can be decreased to safe levels by the use of phototherapy or exchange transfusion.
These findings were similar to previous study [22, 23] and might be explained by the fact that lower unconjugated bilirubin
could not result in renal damage of newborns.
For bilirubin to be excreted from the body it must be water soluble (conjugated), as unconjugated bilirubin
is fat soluble and can potentially be deposited in the body's tissues (McIntosh and Stenson, 2008).
is insoluble in water but highly soluble in lipids.
Fetal bilirubin metabolism is characterised by accumulation of unconjugated bilirubin
because of immature enzymatic activity of bilirubin-uridine-glucuronosyltransferase.
is poorly soluble in serum; therefore it is transported to liver bound to albumin.
Markedly greater elevations of unconjugated bilirubin
relative to elevations of conjugated bilirubin in the blood suggest hemolysis (destruction of red blood cells).
It is widely held, based on both laboratory investigations and epidemiologic studies, that unconjugated bilirubin
is toxic to the central nervous system.