uncompetitive inhibitor


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uncompetitive inhibitor

a type of enzyme inhibitor in which the inhibiting compound only binds to the enzyme-substrate complex.

un·com·pet·i·tive in·hib·i·tor

(ŭn'kŏm-pet'i-tiv in-hib'i-tŏr)
A type of enzyme inhibitor in which the inhibiting compound only binds to the enzyme-substrate complex.
References in periodicals archive ?
Dehydroepiandrosterone (DHEA) is a natural, uncompetitive inhibitor of G6PD.
One of the metabolites, urolithin A, was the most potent uncompetitive inhibitor of CYP1B1 exhibiting two fold selectivity over CYP1A1, while another, urolithin B, was a noncompetitive inhibitor with three fold selectivity.
An uncompetitive inhibitor of IMPDH inhibits by binding at the active site of the enzyme and does not compete with IMP or NAD for inhibition of the enzyme.
The first property is that an uncompetitive inhibitor as a target conjugate is preferred over a competitive inhibitor because uncompetitive inhibitors are rare in nature and should be less susceptible to interferences from drugs and naturally occurring substances, which frequently are competitive inhibitors of enzymes.
Saifi, "Mushroom tyrosinase inhibition by two potent uncompetitive inhibitors," Journal of Enzyme Inhibition and Medicinal Chemistry, vol.
In contrast, both [gamma]-mangostin and garcinone C are uncompetitive inhibitors, while [alpha]-mangostin is a mixed-mode inhibitor of BChE.
In this study, most of the samples are uncompetitive inhibitors and one advantage of these inhibitors is that they would be effective at lower concentrations of substrate in comparison with competitive inhibitors which require higher concentrations of the substrate for the same effects.
rhynchophylla were uncompetitive inhibitors with respect to the substrate benzylamine (Fig.