unblinding

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unblinding

A term of art used in clinical trials for the identification of the treatment code of a subject/patient or grouped results in studies where the treatment assignment was unknown to the subject and investigators.
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"Justice Unblind: The Juries and the Criminal Classes in France, 1825-1914." Journal of Social History 15.1 (1981): 89-103.
Studies (3,4) have shown that the quality of reviews differs little if blinded or unblinded. In professions such as chiropractic, where there is a small base of active researchers, virtually everyone knows what research others are involved with and can identify the authors even when blinded.
The results were so dramatic that researchers "unblinded" the trial, so all the patients could receive the combination treatment.
The investigators chose to unblind their study at that point before all the patients they intended to treat had been enrolled.
In the second half of 2001, we will unblind data from our first two clinical programs: our Phase III trial of Aldurazyme for the treatment of MPS-I and our Phase I trial of rhASB for the treatment of MPS-VI.
Subjects then completed an unblind baseline session in the CEF to reduce initial anxiety and to familiarize them with the procedures and surroundings.
They claimed the US study had been compromised by a decision to "unblind it" - telling the women involved who were receiving the drug and who were being given a dummy treatment instead.
Blind and unblind quality control samples are available from various organizations.
Likewise, those who unblind studies, drop out, alter dosages, and take off-protocol drugs threaten to harm their fellow research subjects by altering the risk-benefit ratio of the study.
The recommendation to stop and unblind the clinical study at this interim analysis was made by an independent data monitoring committee based on pre-specified criteria, specifically, achieving a statistically significant difference from placebo in delaying time to relapse based upon the interim analysis after 42 relapse events have occurred.
Software tools at all levels of the stack will make it impossible to unblind a study by the wrong user.
Agennix decided to unblind the data from the trial to examine better these results.