The study also looked at three additional brain biomarkers to assess any association between elevated levels of those proteins and brain injury: S100 calcium-binding protein B (S100B); ubiquitin C-terminal hydrolase L1 (UCH-L1
) and neuron-specific enolase (NSE) protein.
The test looks for proteins called GFAP and UCH-L1
that are found in our brains and released into blood after an injury.
The test would measure levels of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1
), biomarkers typically released from the brain into the bloodstream after a head injury.
The GFAP, UCH-L1
, NF-L and Tau biomarkers, which reflect different aspects of the ongoing brain cell damage following TBI, were measured in repeated samples of cerebrospinal fluid from the severe trauma patients in NeuroVive's CHIC study.
The assay works by measuring levels of proteins, known as UCH-L1
and GFAP, that are released from the brain into the blood after a hit to the head.
TUESDAY, July 31, 2018 (HealthDay News) -- A combined test of ubiquitin C-terminal hydrolase-L1 (UCH-L1
) and glial fibrillary acidic protein (GFAP) assay results has high sensitivity for detection of intracranial injury among patients with traumatic brain injury (TBI), according to a study published online July 24 in The Lancet Neurology.
According to the company, the Brain Trauma Indicator works by measuring levels of proteins, known as UCH-L1
and GFAP, that are released from the brain into blood and measured within 12 hours of head injury.
In human, four UCHs are grouped into smaller UCHs (UCH-L1
and UCH-L3) that prefer to cleave small leaving groups from the C-terminal of Ub and larger UCHs (UCH37 and BAP1) that hydrolyze polyubiquitin chains .
In humans, four ubiquitin carboxy-terminal hydrolase (UCH) proteins (UCH-L1
, UCH-L3, UCH37/uCh-L5, and BAP1) have been identified, but only UCH-L1
and L3 have been studied in detail .
We examined the association between autism and serum transactive response DNA-binding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1
) levels, both of which are members of the ubiquitin-proteosome system.
Wada, "The functions of UCH-L1
and its relation to neurodegenerative diseases," Neurochemistry International, vol.
In a multicenter trial, levels of the enzyme ubiquitin C-terminal hydrolase (UCH-L1
) rose significantly in severely injured brains, an increase that paralleled the rise in cerebral spinal fluid and correlated with the Glasgow Coma Scale (GCS) score, Dr.