UCHL1

(redirected from Uch-L1)

UCHL1

A gene on chromosome 4p14 that encodes a ubiquitin-protein hydrolase, involved both in processing of ubiquitin precursors and ubiquitinated proteins, which recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds free monoubiquitin and may prevent its degradation in lysosomes.
References in periodicals archive ?
If further study confirms the value of UCH-L1 as the first clinical biomarker in traumatic brain injury (TBI), physicians will be better able to identify targets for drug therapy and guide the timing of treatment with such agents as tissue plasminogen activator, she explained.
Ventricular CSF was drained from each patient at 6, 12, 24, 48, 72, and 96 hours after TBI and was measured by enzyme-linked immunosorbent assay for UCH-L1 levels.
Mean 12-hour UCH-L1 levels were 145 ng/mL for patients with GCS scores of 3-5, and 38.
In this study, EPO in ischemic stroke patients improved neurological outcome and UCH-L1 alone differentiates between placebo and EPO treated patients and correlates with clinical outcome.