Mass spectrometric analysis of lysine ubiquitylation
reveals promiscuity at site level.
Yarden, "Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation
," Cell Research, vol.
Nrf2 has been proved to be maintained at a low level through Keap1-mediated ubiquitylation
and 26S proteasome-mediated degradation.
Osley, "Rad6 plays a role in transcriptional activation through ubiquitylation
of histone H2B," Genes & Development, vol.
of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation," The EMBO Journal, vol.
Up to now, over 60 histone modifications including acetylation, methylation, phosphorylation, and ubiquitylation
have been identified, either by specific antibodies or spectrophotometric techniques .
In recent years, it has been demonstrated that the dynamic association of histones and their variants to the genome plays a very important role in chromatin structure, while their post-translational modifications--acetylation, phosphorylation, methylation, ubiquitylation
and ADP-ribosylation--participate in chromatin function and gene regulation (Berger, 2001).
Citation: "Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation
"; Xudong Wu et al.; Molecular Cell, 2013; DOI: 10.1016/j.molcel.2013.01.016
is a regulated posttranslational modification of proteins in which an ubiquitin molecule is attached to a lysine amino acid in the target protein [15, 16].
Degradation of p63[alpha] is also promoted by the E3 ubiquitin ligase ITCH via ubiquitylation
at the N-terminal border of the SAM domain of the p63[alpha] isoforms .
of an ERAD substrate occurs on multiple types of amino acids," Molecular Cell, vol.
Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation