ubiquitin

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u·biq·ui·tin

(ū-bik'kwi-tin), [MIM*191320]
A small (76 amino acyl residues) protein found in all cells of higher organisms and one with a structure that has changed minimally during evolutionary history; involved in at least two processes; histone modification and intracellular protein breakdown.

ubiquitin

(yo͞o-bĭk′wĭ-tĭn)
n.
A small protein found in all eukaryotic cells that attaches to other proteins, thereby regulating their activity or location or marking them for degradation.

ubiquitin

[yo̅o̅bik′witin]
a small polypeptide that is involved in histone modification and is a marker for intracellular protein transport and breakdown. It is found in all cells of higher organisms.

u·bi·qui·tin

(yū-bik'kwi-tin)
A small protein found in all cells of higher organisms; its structure has changed minimally during evolutionary history; involved in histone modification and intracellular protein breakdown.

ubiquitin

A small 76-residue protein found in all animal cells and known to have altered minimally throughout evolutionary history. Ubiquitin is linked by covalent bonds to proteins destined for destruction by PROTEASOMES.

ubiquitin

a small PROTEIN, present in all eukaryotic cells (ubiquitous protein), containing a highly conserved sequence of 76 AMINO ACIDS, that is identical in a wide range of organisms including humans, fish and insects. Ubiquitin is involved in a number of cellular functions, such as protein degradation and modifications to CHROMATIN structure.

ubiquitin (yōōˈ·biˑ·kwi·tin),

n a 76-amino acid polypeptide from modification of histones; present in yeast and in most eukaryotic cells.

ubiquitin

heat shock (cell stress) protein present in mammalian cytosol; attaches to other cytosolic proteins and marks them for degradation either by specific proteases or by lysosomal enzymes.
References in periodicals archive ?
Taken together, these data suggest that PRC1-mediated histone H2A ubiquitylation and PCR2-mediated histone H3 methylation may regulate plant cell identity (Bratzel et al.
Many types of epigenetic processes have been identified--they include methylation, acerylation, phosphorylation, ubiquitylation, and sumolyation.
Moreover, a recent study of the binding of the SAM analog sinefungin to TPMT from Pseudomonas syringae suggested that substrate binding leads to conformational stability of peripheral structural elements of the enzyme as well as an increase in backbone mobility that may protect variant and, by implication, wild-type TPMT enzymes from ubiquitylation and degradation (20).
This linkage process, called ubiquitylation, requires three classes of enzymes: (1) E1 enzymes, which activate the ubiquitin, (2) E2 enzymes, which bind to the ubiquitin molecule, and (3) E3 enzymes, which transfer the ubiquitin molecule to the target protein.
Chapter 15 Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation
I will monitor RNF4-dependant ubiquitylation changes in response to ionising radiation, hydroxyurea and camptothecin; conditions that induce distinct types of DNA damage.
Michael Rape - Ubiquitylation is a process that occurs in all cells; the details of how the small protein termed "ubiquitin" modifies proteins and regulates cellular processes, however, are not yet well understood.
This is followed by ubiquitylation and rapid proteosomal degradation of HIF-1[alpha].