USP14

(redirected from Ubiquitin-specific processing protease 14)

USP14

A gene on chromosome 18p11.32 that encodes a deubiquitinase which releases ubiquitin from the proteasome-targeted ubiquitinated proteins, ensuring that ubiquitin is regenerated at the proteasome. USP14 is required for the degradation of the chemokine receptor CXCR4, which is critical for CXCL12-induced cell chemotaxis, and serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) by inhibiting the degradation of unfolded ER proteins via interaction with ERN1. USP14 is required for synaptic development and function at neuromuscular junctions.
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