UBE2K

(redirected from Ubiquitin-protein ligase)

UBE2K

A gene on chromosome 4p14 that encodes a ubiquitin-conjugating enzyme which interacts with RING finger proteins. It ubiquitinates huntingtin, a protein linked to Huntington's disease, the known functions of which include a role in aggregate formation of polyglutamine proteins and apoptosis suppression in polyglutamine diseases, as well as a role in releasing newly synthesised MHC class-I heavy chains from the endoplasmic reticulum.

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In addition, deficit or excess ubiquitin-protein ligase E3A (UBE3A) leads to autistic symptoms in the Angelman syndrome.

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome.

Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin-Proteosome System in Autism Spectrum Disorder?

Cullin-5 is a core component of Elongin-Cullin 2/5-SOCS-box protein E3 ubiquitin-protein ligase complexes, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [29].

Huaiqihuang may protect from proteinuria by resisting MPC5 podocyte damage via targeting p-ERK/CHOP pathway

ITCH (E3 ubiquitin-protein ligase Itchy homolog), a known Txnip interactor, was identified as an E3 ubiquitin ligase for Txnip.

Identification of Redox and Glucose-Dependent Txnip Protein Interactions

Ubiquitination of proteins is mediated by the ubiquitin-protein ligase complex, which consists of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin-ligating enzyme (E3).

Intracellular lectins are involved in quality control of glycoproteins

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.

Parkin and Parkinson disease

The researchers then compared the gene with that in normal rats to find that only diabetes-afflicted rats showed ''nonsense mutation'' in Cb1b, a kind of ubiquitin-protein ligases, they said in the journal.