UBE2K

(redirected from Ubiquitin-protein ligase)

UBE2K

A gene on chromosome 4p14 that encodes a ubiquitin-conjugating enzyme which interacts with RING finger proteins. It ubiquitinates huntingtin, a protein linked to Huntington's disease, the known functions of which include a role in aggregate formation of polyglutamine proteins and apoptosis suppression in polyglutamine diseases, as well as a role in releasing newly synthesised MHC class-I heavy chains from the endoplasmic reticulum.
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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.
De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome.
The researchers then compared the gene with that in normal rats to find that only diabetes-afflicted rats showed ''nonsense mutation'' in Cb1b, a kind of ubiquitin-protein ligases, they said in the journal.

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