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Related to Ubiquitin proteasome pathway: Ubiquitin proteasome system


Cytoplasmic organelle, composed of a cylindric core particle bound by two regulatory particles at each end, responsible for degrading endogenous proteins. Proteins to be destroyed are recognized by proteasomes because of the presence of ubiquitin conjugated to the targeted protein's lysine residue.
See also: ubiquitin-protease pathway.
[protease + -some ]


A cellular protein complex consisting of proteolytic enzymes that degrade endogenous proteins, especially those that are damaged, pathogenic, or no longer of use.


, proteosome (prō′tē-ă-sōm″)
An enzymatic (protease) cell organelle that degrades misfolded or damaged proteins and modulates the quantity of regulatory proteins in the cell. The breakdown of proteins by proteasomes (proteolysis) is triggered when damaged proteins are tagged by ubiquitin.


A large, cylindrical protein complex of several sub-units, present in the cytoplasm and nucleus of all cells and an essential component in cell metabolism. The function of the proteasome is to act as a kind of shredder, degrading unwanted proteins that have been tagged for destruction with UBIQUITIN chains. It strips proteins of their ubiquitin, unfolds them and catalyzed them to peptides. Proteasomes have aroused much interest as therapeutic trargets in cancer. The proteasome 26S is involved both in the induction and repression of APOPTOSIS. See also POLYUBIQUITINATION.
References in periodicals archive ?
a Malvern, Pennsylvania, based biotechnology company for distribution of LifeSensors' Ubiquitin Proteasome Pathway (UPP) research tools and novel recombinant protein expression technologies in Japan, Singapore, South Korea and Taiwan.
Cognia's first database, Cognia Ubiquitin Database, a comprehensive summary of E3 ligases and other Ubiquitin Proteasome Pathway proteins, is being launched later this month; a second already is in production and will be announced shortly.
This technology, related to the universal intracellular pathway for protein turnover, is referred to as the ubiquitin proteasome pathway, which regulates the level of cellular proteins.

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