UBE2K

(redirected from Ubiquitin carrier protein)

UBE2K

A gene on chromosome 4p14 that encodes a ubiquitin-conjugating enzyme which interacts with RING finger proteins. It ubiquitinates huntingtin, a protein linked to Huntington's disease, the known functions of which include a role in aggregate formation of polyglutamine proteins and apoptosis suppression in polyglutamine diseases, as well as a role in releasing newly synthesised MHC class-I heavy chains from the endoplasmic reticulum.
Mentioned in ?
References in periodicals archive ?
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.
Identification ofthe ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

Full browser ?