In another study, 73% of patients who received oral vitamin E and narrow-band UVB phototherapy
had marked to excellent repigmentation, compared with 55.6% of those who had photo therapy only (J Clin Pharmacol.
The implications of vitamin D deficiency in dermatological disorders are multiple and the beneficial effects of UVB radiation on psoriasis lesions have been documented by using UVB phototherapy
with wavelengths of 280-320 nm in 1980 in studies in Japan and US, following in 1996 the effectiveness of vitamin D therapy to be demonstrated.
As per the data pertaining to the 2-year study period, 33 patients of vitiligo were prescribed narrow band UVB phototherapy
, of which 11 patients dropped out within less than 8 sessions of phototherapy.
PUVA (psoralen and UVA) therapy, as well as UVB phototherapy
have been successful at preventing flares in several studies.
Potent topical corticosteroids, topical calcineurin inhibitors, keratolytic agents, topical dimethyl sulfoxide (DMSO), intralesional corticosteroids, PUVA and UVB phototherapy
, systemic retinoids, low-dose cyclophosphamide, cyclosporine have been used for medical management of LA.7
Light therapy for the condition can be as simple as exposure to sunlight, and progress to UVB phototherapy
, narrowband UVB therapy, a combination treatment of UVB and coal tar, photochemotherapy or psoralen plus ultraviolet A, Excimer laser, pulsed dye laser and combination light therapy.
Another study done by Tahir R, included forty patients of chronic plaque psoriasis and compared the effects of PUVA or UVB and found that treatment with PUVA resulted in clearance of psoriasis in significantly greater number of patients (85%) compared to UVB (65%) with fewer number of exposures.11 They concluded that PUVA was more effective treatment of psoriasis compared to narrow band UVB phototherapy
Photocarcinogenic risk of narrowband UVB phototherapy
: early follow-up data.
Objectives: To compare the efficacy of twice weekly and thrice weekly narrow band UVB phototherapy
in terms of Psoriasis Area Severity Index (PASI) scoring in patients with Chronic Plaque Psoriasis (CPP) having skin type III - V.
This treatment applied in our institute consists of a balneotherapy with the medicinal water and, depending on the severity of the dermatological symptoms, a local non-steroidal ointment treatment (Dithranol) and a narrowband (311 nm) UVB phototherapy
. During the retrospective processing of the data of our ward's psoriasis affected patients who were treated in the above mentioned period, we took as a principal aspect of the assessment the local effect of the applied treatment to the dermatological symptoms.
"Treatment options, depending upon many factors, include corticosteroids, PUVA, Narrow-band UVB phototherapy
, topical tacrolimus, laser treatments, skin grafting, transplantation of cultured melanocytes, and de-pigmentation."