USP7


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USP7

A gene on chromosome 16p13.3 that encodes an enzyme which deubiquitinates target proteins (e.g., FOXO4, p53/TP53, MDM2, PTEN and DAXX). USP27 forms a complex with DAXX, MDM2 and RASSF1. It is widely expressed in various tissues and overexpressed in prostate cancer.
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To date, several DUBs are found to regulate osteoblast function (USP4, USP7, USP9x, USP15, UCH-l3, and MYSM1) and osteoclast function (CYLD, USP15, USP18, A20, and POH1) (Table 2).
Li et al., "Protein deubiquitinase USP7 is required for osteogenic differentiation of human adiposederived stem cells," Stem Cell Research & Therapy, vol.
Song et al., "Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis," The Journal of Clinical Investigation, vol.
Suresh Kumar, "The multifaceted roles of USP7: new therapeutic opportunities," Cell Biochemistry and Biophysics, vol.
Tan et al., "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response, " Blood, vol.
dUb Target Ubiquitin-mediated Biological molecules modifications function A20 RIP1, RIP2, TRAF2, K63 Signaling TRAF6, MALT1, NEMO termination CYLD MyD88, TRAF2, K63 Signaling TRAF6, TRAF7, termination RIP1, NEMO USP2[alpha] TRAF6 K63 Signaling termination USP4 TRAF2, TRAF6, TAK1 K63 Signaling termination USP7 TRAF6, NEMO K63 Signaling termination USP10 TRAF6, NEMO K63/M1 Signaling termination USP11 IxBa K48 Proteolytic degradation USP15 IxBa K48 Proteolytic degradation USP18 TAK1, NEMO K63 Signaling termination USP21 RIP1 K63 Signaling termination USP25 TRAF2, TRAF3, K63/K48 Signaling TRAF5, TRAF6 termination/ proteolytic degradation Table 4: TLR expression profile.
Data presented in the research article entitled Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes (Chemistry & Biology, Volume 18, Issue 11, 1401-1412, 23 November 2011) confirms the selective inhibition of USP7 in human cells treated with P022077, contrary to the pan-DUB inhibition profile of the tool compound PR-619 in the same cells.