USP44

USP44

A gene on chromosome 12q22 that encodes a deubiquitinase which plays a key role in the mitotic spindle checkpoint by preventing the premature onset of anaphase. USP44 deubiquitinates CDC20, a negative regulator of the anaphase-promoting complex/cyclosome (APC/C), stabilising the MAD2L1-CDC20-APC/C ternary complex (i.e., mitotic checkpoint) and preventing premature APC/C activation. USP44 is transcriptionally regulated by POU5F1/OCT4 in embryonic stem cells.
References in periodicals archive ?
Among these 9 SNPs, 3 of them were located between 45.43 Mb and 45.61 Mb of chromosome 1 with the nearest genes being ubiquitin specific peptidase 44 (USP44), leukotriene A4 hydrolase (LTA4H), and ETS transcription factor (ELK3), respectively.
Functional study showed that USP44 prevents the premature activation of the anaphase-promoting complex and regulating centrosome separation, positioning, and mitotic spindle geometry.
Family Members USPL1, CYLD, USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP YSP8, USP9x, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17L2, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 OTUB1, OTUB2, OTUD1, OTUD3, OTUD4, OTUD5, OTUD6A, OTU OTUD6B, OTU1, HIN1L, A20, Cezanne, Cezanne2, TRABID, VCPIP1 UCH UCH-L1, UCH-L3, UCH37/UCH-L5, BAP1 Josephin ATXN3, ATXN3L, JOSD1, JOSD2 JAMM/MPN+ BRCC36, CSNS, POH1, AMSH, AMSH-LP, MPND, MYSM1, PRPF8 Table 2: Deubiquitinases and bone remodeling.
In yet another layer of regulation, the deubiquitinase activity of USP44 and ubiquitin-binding and stabilization activity of HDAC6 work to balance the ubiquitination state of Cdc20.