USP4


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USP4

A gene on chromosome 3p21.3 that encodes an enzyme which deubiquitinates target proteins (e.g., ADORA2A, PDPK1 and TRIM21), increasing the amount of functional receptors at the cell surface. USP4 plays a role in regulating quality control in the endoplasmic reticulum; it interacts with RB1, RBL1 and RBL2 and is expressed in the hippocampus.
 
Molecular pathology
USP4 is overexpressed in small cell carcinomas and adenocarcinomas of the lung.
References in periodicals archive ?
To date, several DUBs are found to regulate osteoblast function (USP4, USP7, USP9x, USP15, UCH-l3, and MYSM1) and osteoclast function (CYLD, USP15, USP18, A20, and POH1) (Table 2).
Lindsten, "The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway," Journal of Cellular and Molecular Medicine, vol.
Drabsch et al., "USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-[beta] type I receptor," Nature Cell Biology, vol.
Liu et al., "AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4," BMC Cell Biology, vol.
Mao et al., "USP4 targets TAK1 to downregulate TNF[alpha]-induced NF-[kappa]B activation, " Cell Death and Differentiation, vol.
Luo et al., "Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFa-induced cancer cell migration, " Biochemical Journal, vol.
dUb Target Ubiquitin-mediated Biological molecules modifications function A20 RIP1, RIP2, TRAF2, K63 Signaling TRAF6, MALT1, NEMO termination CYLD MyD88, TRAF2, K63 Signaling TRAF6, TRAF7, termination RIP1, NEMO USP2[alpha] TRAF6 K63 Signaling termination USP4 TRAF2, TRAF6, TAK1 K63 Signaling termination USP7 TRAF6, NEMO K63 Signaling termination USP10 TRAF6, NEMO K63/M1 Signaling termination USP11 IxBa K48 Proteolytic degradation USP15 IxBa K48 Proteolytic degradation USP18 TAK1, NEMO K63 Signaling termination USP21 RIP1 K63 Signaling termination USP25 TRAF2, TRAF3, K63/K48 Signaling TRAF5, TRAF6 termination/ proteolytic degradation Table 4: TLR expression profile.