USP36

USP36

A gene on chromosome 17q25.3 that encodes a C19 family peptidase which may be required for maintaining adult stem cells, downregulating transcription by continually deubiquitinating histone H2B at the promoters of genes critical for cellular differentiation.
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Through our GO network analysis, 17 of 73 genes, i.e., ATP binding cassette subfamily A member 13 (ABCA13), actin alpha2 (ACTN2), ATPase phospholipid transporting 9A (ATP9A), C2 calcium dependent domain containing 3 (C2CD3), centrosomal protein 152 (CEP152), growth hormone (GH), glucagon like peptide 2 receptor (GLP2R), GNAS complex locus (GNAS), interleukin 22 receptor subunit alpha 2 (IL22RA2), microtubule associated protein 1 light chain 3 beta (MAP1LC3B), I-BAR domain containing (MTSS1), olfactomedin 1 (OLFM1), slowmo homolog 2 (SLMO2), prominin 1 (PROM1), sperm associated antigen 5 (SPAG5), transforming growth factor beta receptor 3 (TGFBR3), ubiquitin specific peptidase 36 (USP36), were found associated with six major GO terms.
Family Members USPL1, CYLD, USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP YSP8, USP9x, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17L2, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 OTUB1, OTUB2, OTUD1, OTUD3, OTUD4, OTUD5, OTUD6A, OTU OTUD6B, OTU1, HIN1L, A20, Cezanne, Cezanne2, TRABID, VCPIP1 UCH UCH-L1, UCH-L3, UCH37/UCH-L5, BAP1 Josephin ATXN3, ATXN3L, JOSD1, JOSD2 JAMM/MPN+ BRCC36, CSNS, POH1, AMSH, AMSH-LP, MPND, MYSM1, PRPF8 Table 2: Deubiquitinases and bone remodeling.
The Usp9x, Usp30, Usp36, and ataxin-3 may preserve mitochondrial protein degradation by editing or removing the degradative ubiquitin signal [113, 136-138].