USP33

USP33

A gene on chromosome 1p31.1 that encodes a deubiquitinating enzyme involved in:
• Cell migration via its interaction with intracellular domain of ROBO1, which regulates Slit signalling;
• Slit-dependent commissural axon guidance across the ventral midline of the neural tube, possibly by mediating ROBO1 deubiquitination;
• Regulating G protein-coupled receptor (GPCR) signalling by deubiquitinating beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2);
• ADRB2 recycling and resensitisation after prolonged agonist stimulation; and
• DIO2 deubiquitination and thyroid hormone regulation.
USP33 mediates deubiquitination of 'Lys-48'- and 'Lys-63'-linked polyubiquitinated chains.
References in periodicals archive ?
"A lingua pura na teoria da tradugao de Walter Benjamin", Revista USP33, 160-171.
Family Members USPL1, CYLD, USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP YSP8, USP9x, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17L2, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 OTUB1, OTUB2, OTUD1, OTUD3, OTUD4, OTUD5, OTUD6A, OTU OTUD6B, OTU1, HIN1L, A20, Cezanne, Cezanne2, TRABID, VCPIP1 UCH UCH-L1, UCH-L3, UCH37/UCH-L5, BAP1 Josephin ATXN3, ATXN3L, JOSD1, JOSD2 JAMM/MPN+ BRCC36, CSNS, POH1, AMSH, AMSH-LP, MPND, MYSM1, PRPF8 Table 2: Deubiquitinases and bone remodeling.