USP3

USP3

A gene on chromosome 15q22.3 that encodes an enzyme which deubiquitinates monoubiquitinated target proteins, such as histones H2A and H2B. USP3 is required for progression through S-phase and mitotic entry; it may regulate the DNA damage response (DDR) checkpoint by deubiquitinating H2A at DNA damage sites. It associates with chromatin and is expressed in all tissues, especially the pancreas.
References in periodicals archive ?
Vissers et al., "Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells," The Journal of Experimental Medicine, vol.
To prevent its overactivation, RIG-I is actively targeted by many cellular factors that inhibit K63 ubiquitination (CYLD, USP1, and USP3) or tag it for proteasome degradation via K48 ubiquitin linkage (RNF122, RNF125) [19-23].
The DUBs that catalyze both H2A and H2B are USP3 and USP22.
Eugene Generals goaltender Christopher Alexakis has been named by the United States Premier Hockey League as the USP3's goaltender odf the week.
For example, a meta GWAS of incident heart failure (HF) identified a single HF-associated locus near the USP3 (3) (ubiquitin specific peptidase 3) gene (5).
Also in 2007,with help from the Federal Bureau of Investigation (FBI), FEBs nationwide were granted access to the Law Enforcement On-Line (www.leo.gov) and United States Public and Private Partnership (usp3.org) communications systems.
Public Private Partnership (USP3), an industry-funded nonprofit organization, plans to launch its own situational awareness Web- and message system based on HSIN CI and the FBI's Emergency Response Network (FBI ERN).
Dclre1a cerevisiae) BG069818 ubiquitin specific protease 3 Usp3 BG075881 tyrosine 3-monooxygenase/tryptophan Ywhaz 5-monooxygenase activation protein, zeta polypeptide GenBank Fold change (a) accession no.
Public-Private Partnership (called USP3), which is an information sharing initiative coordinated by the Department of Justice.