USP28

USP28

A gene on chromosome 11q23 that encodes a deubiquitinase involved in DNA damage response, which interacts with isoform 1 of FBXW7; following DNA damage, it and dissociates from FBXW7 leading to degradation of MYC. USP28 is involved in DNA damage-induced apoptosis by deubiquitinating certain proteins of the DNA  damage pathway (e.g., CLSPN). It is also acts at the G2 DNA damage checkpoint by deubiquitinating CLSPN and preventing its degradation by the anaphase-promoting complex/cyclosome (APC/C). It is downregulated by hypoxia.
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Family Members USPL1, CYLD, USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP YSP8, USP9x, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17L2, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 OTUB1, OTUB2, OTUD1, OTUD3, OTUD4, OTUD5, OTUD6A, OTU OTUD6B, OTU1, HIN1L, A20, Cezanne, Cezanne2, TRABID, VCPIP1 UCH UCH-L1, UCH-L3, UCH37/UCH-L5, BAP1 Josephin ATXN3, ATXN3L, JOSD1, JOSD2 JAMM/MPN+ BRCC36, CSNS, POH1, AMSH, AMSH-LP, MPND, MYSM1, PRPF8 Table 2: Deubiquitinases and bone remodeling.
Another putative MNRR1 target gene is USP28 (ubiquitin-specific peptidase 28), which encodes a deubiquitinating enzyme that contributes to DNA damage-induced activation of apoptosis [86], another key pathway with which MNRR1 is associated [27].
Elledge, "A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response," Cell, vol.
For example, KIF1C (kinesin family member 1C) and USP28 (ubiquitin specific peptidase 28) mutations, which are clonally expanded in metastasis, preexist at levels of [less than or equal to] 1% in primary breast tumors (8), and clinical resistance-causing KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (gastrointestinal stromal tumor) and EGFR (lung adenocarcinoma) mutations can be present in tumors at levels <<1% (36, 37).
[5] Human genes: TET2, tet methylcytosine dioxygenase 2; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; TP53, tumor suppressor protein 53; IDH1, isocitrate dehydrogenase subunit 1 ([NADP.sup.+]), soluble; EGFR, epidermal growth factor receptor; KIF1C, kinesin family member 1C; USP28, ubiquitin specific peptidase 28; KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.
(2) Current industry applicable documents such as the ISPE Baseline Guide for Water and Steam Systems (2) or Chapter 1231 of the United States Pharmacopoeia (USP28) (3) are excellent references that discuss the considerations for Good Engineering Practices for Pharmaceutical Waters.