USP25

USP25

A gene on chromosome 21q11.2 that encodes a deubiquitinating enzyme which hydrolyses ubiquitin moieties conjugated to substrates. USP25 processes newly synthesised ubiquitin, recycles ubiquitin molecules or edits polyubiquitin chains, and it prevents proteasomal degradation of substrates. It is widely expressed in most adult and foetal tissues.
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In candidate gene studies, single-nucleotide polymorphisms (SNPs) in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD.[15] RBD patients who carried the USP25 SNP rs2823357 converted to a-synucleinopathies faster than who did not.[15] Patients with PD who carried GBA mutation had an odds ratio ( OR ) of 6.24 for RBD and an OR of 3.13 for probable RBD.[16] Carriers of the PINK1 SNP rs45478900 among BRD patients have a higher risk for conversion to PD ( OR : 2.92) than noncarriers.[17] However, it seemed that the APOE*?4 allele was not associated with both the risk of RBD occurrence and its conversion to any a-synucleinopathy.[18]
Family Members USPL1, CYLD, USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP YSP8, USP9x, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17L2, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 OTUB1, OTUB2, OTUD1, OTUD3, OTUD4, OTUD5, OTUD6A, OTU OTUD6B, OTU1, HIN1L, A20, Cezanne, Cezanne2, TRABID, VCPIP1 UCH UCH-L1, UCH-L3, UCH37/UCH-L5, BAP1 Josephin ATXN3, ATXN3L, JOSD1, JOSD2 JAMM/MPN+ BRCC36, CSNS, POH1, AMSH, AMSH-LP, MPND, MYSM1, PRPF8 Table 2: Deubiquitinases and bone remodeling.
The DUBs, A20, CYLD, USP2, USP4, USP7, USP10, USP18, USP21, and USP25 terminate NF-[kappa]B signaling by removing K63-linked ubiquitin chains from signaling molecules [101-123].
Zhang et al., "Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6, " Proceedings of the National Academy of Sciences of the United States of America, vol.
Wang et al., "Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25, " Nature Immunology, vol.
El factor 8 regulador del interferon (IRF-8), el cual pertenece a un grupo de proteinas reguladoras de la respuesta inmune (34,35); el gen USP25 relacionado no solo con la degradacion de proteinas sino tambien con procesos de control celular, trafico de proteinas y remodelacion de la cromatina, entre otros (36); todos ellos estarian participando de redes de expresion de genes cruciales para el control de procesos asociados con la leukomogenesis y de descontrol del ciclo celular que se asocian con LLCTA.
del trasporte de electrones SDCBP 8q12 Proteina de enlace Positiva al receptor 5 de interleuquina IRF8 16q24 Proteina Negativa CDKN2A 9p21.3 Proteina que Positiva interviene en la fragmentacion del ADN para la apoptosis celular USP25 21q21.1 Proteina que Negativa interviene en la degradacion de proteinas
For optimized performance, Millipore water purification systems combine the latest technologies to produce Reagent-grade, Type I, NCCLS, USP25, ASTM, and CAP ultrapure water quality.