USP18

A gene on chromosome 22q11.21 that encodes a C19 ubiquitin-specific peptidase which only efficiently cleaves ISG15 fusions. It is required for maintaining a critical intracellular balance of ISG15-conjugated proteins in normal and stressed organisms.

References in periodicals archive ?

IFN-lambda4 desensitizes the response to IFN-alpha treatment in chronic hepatitis C through long-term induction of USP18. TJ Gen Virol 2016;97:2210-20.

The immune profile in HIV: A useful signature in future HIV research?

To date, several DUBs are found to regulate osteoblast function (USP4, USP7, USP9x, USP15, UCH-l3, and MYSM1) and osteoclast function (CYLD, USP15, USP18, A20, and POH1) (Table 2).

Tse, "Deubiquitinase Usp18 prevents cellular apoptosis from oxidative stress in liver cells," Cell Biology International, vol.

Deubiquitinating Enzymes and Bone Remodeling

Only EIF2AK2, NAMPT, and NT5C3 and the ubiquitin-related gene USP18 overlapped as top classifiers across datasets.

Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses

Lipopolysaccharide and tumor necrosis factor alpha inhibit interferon signaling in hepatocytesby increasing ubiquitin-like protease 18 (USP18) expression.

The regulatory role of IL-6R in hepatitis B-associated fibrosis and cirrhosis

The baseline expression levels of 25 IFN-regulated genes (MxA, GPR3, IL17RC, ISG15, TRAIL, OASL, IFIT1, IFIT2, RSAD2, OAS3, IFI44L, TRIM22, IL10, CXCL10, STAT1, OAS1, OAS2, IFNAR1, IFNAR2, IFN[beta], ISG20, IFI6, PKR, IRF7, and USP18) were examined but were not confirmed to have predictive value [53].

Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives

The DUBs, A20, CYLD, USP2, USP4, USP7, USP10, USP18, USP21, and USP25 terminate NF-[kappa]B signaling by removing K63-linked ubiquitin chains from signaling molecules [101-123].

Interplay between Inflammation and Sternness in Cancer Cells: The Role of Toll-Like Receptor Signaling

Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.

Cloning and sequence analysis of wild Argali ISG15 cDNA

Genbank ID Gene Forward primer Reverse primer name NM_024330 SLC27A3 AGAACTTGCCACCTTATGCC CTCATTTGCCATCCGAACTT NM_024330 FATP-3 CAGAGACCTTCAAACAGCAGAAAGT CAGAACGTACAGTGGGTCAGACA NM_004561 OVOL1 ACAGACCCCCAGAGCAGAG GACTGTCCCCAAGGGTCAC NM_000647 CCR2 GTGTGTGGAGGTCCAGGAGT CAACCCAGCTGGAGTCTCTC NM_018098 ECT2 GCGTTTTCAAGATCTAGCATGTG CAATTTTCCCATGGTCTTATCC NM_000418 IL-4Ra GAC CTG GAG CAA CCC GTA CAT AGC ACA ACA GGC AGA TC CG NM_017414 USP18 CAGACCCTGACAATCCACCT AGCTCATACTGCCCTCCAGA NM_000452 SLC10A2 ACGCAGCTATGTTCCACCATC GCGGGAAGGTGAATACGACA NM_003959 H1P1R AGCCTCCGACATGCTGTACT GTCGTCCTTCACAGACCCAT NM_138285 NUP35 CTACTCCTGGAACAGGGCAA TCCGAGCCTGCAGTTTAGAT NM_002046.3 CAPDH GTTGGAGGTCGGAGTCAACGCA GAGGGATCTCGCTCCTGGAGGA Antibodies and Western blot analysis

Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns

Upregulation of an 18-gene signature known as USP18 predicted lack of response to treatment, and another study by the same group showed that silencing this gene signature in vitro could improve treatment response.

Genes predict treatment response in hepatitis C

The anti-inflammatory ISGs USP18 and suppressor of cytokine signaling 1-3 (SOCS1-3), however, are specifically induced by IFNLs and not by type I IFNs [58].