USP16

USP16

A gene on chromosome 21q22.11 that encodes an enzyme which specifically deubiquitinates histone H2A (but not H2B), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation of histone H3 and is required for chromosome segregation when cells enter into mitosis. USP16 regulates Hox gene expression via histone H2A deubiquitination. It is also a less preferred gene symbol for what is now designated as USP21, see there. 

Molecular pathology
A chromosomal aberration involving USP16 (inv(21) (q21;q22) with RUNX1/AML1) is a cause of chronic myelomonocytic leukaemia.
References in periodicals archive ?
Family Members USPL1, CYLD, USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP YSP8, USP9x, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17L2, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 OTUB1, OTUB2, OTUD1, OTUD3, OTUD4, OTUD5, OTUD6A, OTU OTUD6B, OTU1, HIN1L, A20, Cezanne, Cezanne2, TRABID, VCPIP1 UCH UCH-L1, UCH-L3, UCH37/UCH-L5, BAP1 Josephin ATXN3, ATXN3L, JOSD1, JOSD2 JAMM/MPN+ BRCC36, CSNS, POH1, AMSH, AMSH-LP, MPND, MYSM1, PRPF8 Table 2: Deubiquitinases and bone remodeling.
The H2A-specific deubiquitinating enzymes (DUBs) are USP16, USP21, 2A-DUB, and BAP1.
Although the gene, called Usp16, is unlikely to be the only contributor to the disease, the finding raises the possibility of an eventual therapy based on reducing its expression.
"We believe Usp16 overexpression is a major contributor to the neurological deficits seen in Down syndrome."
The fact that people with Down syndrome have three copies of chromosome 21 and the Usp16 gene accelerates the rate at which stem cells are used during early development, which likely exhausts stem cell pools and impairs tissue regeneration in adults with Down syndrome.
They also investigated the effect of Usp16 overexpression in human cells.
Conversely, reducing Usp16 expression in skin and nerve-progenitor cells from people with Down syndrome allowed the cells, which usually proliferate slowly, to assume normal growth patterns.
Reducing Usp16 expression gives an unambiguous rescue at the stem cell level.
Para o teor de lipidios, verificou-se que a farofa de casca de vegetais apresentou 15%, valor este maior que o encontrado pela USP16 (13,60%) e TACO15 (9,10%).
(a) Probe set ID Gene symbol Location 200800_s_at HSPA1A 6p21.3 242904_x_at MGC8721 8p12 213281_at JUN 1p32-p31 229264_at FLJ39739 237510_at MYNN 3q26.31 229054_at FLJ39739 202732_at PKIG 20g12-q13.1 229872_s_at KIAA0493 8q24.13 230574_at 224495_at MGC10744 17p13.1 243_g_at MAP4 3p21 244741_s_at MGC9913 19q13.43 221419_s_at 219503_s_at FLJ11036 3p25.1 240406_at USP16 21q22.11 241749_at 9q31.1 228932_at 227667_at 239063_at 236509_at 200655_s_at CALM1 14q24-q31 221384_at UCP1 4q28-q31 203834_s_at TGOLN2 2p11.2 225122_at RNF31 14q11.2 229975_at Probe set ID Gene description 200800_s_at heat shock 70 kDa protein 1A 242904_x_at hypothetical protein MGC8721 213281_at v-jun sarcoma virus 17 oncogene homolog (avian) (b) 229264_at FLJ39739 protein (M.