USP10

USP10

A gene on chromosome 16q24.1 that encodes a widely expressed enzyme which deubiquitinates target proteins (e.g., p53/TP53), counteracting MDM2 action. In response to DNA damage, USP10 translocates to the nucleus and deubiquitinates p53/TP53, thereby regulating the p53/TP53-dependent DNA damage response. It also deubiquitinates CFTR in early endosomes, enhancing endocytic recycling, as well as BECN1, a key regulator of autophagy, leading to stabilisation of PIK3C3/VPS34-containing complexes. USP10 is specifically inhibited by spautin-1. It is also a less preferred gene symbol for what is now designated as USP32, see there.
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Reddy's Laboratories' Phytonadione Injectable Emulsion USP10 mg/ml Single-Dose Ampules introduced in US
The collaboration does not include any of Mission's lead DUB programs including USP30 and USP10.
The m6A repellers preferentially interact with an unmodified RNA sequence but repelled by m6A, such as G3BP1 and G3BP2 known as stress granule proteins [93, 94], USP10 and CAPRINI (interaction partners of G3BP1 and G3BP2), and METTL16, an adenosine methyltransferase for small nuclear RNA.
The DUBs, A20, CYLD, USP2, USP4, USP7, USP10, USP18, USP21, and USP25 terminate NF-[kappa]B signaling by removing K63-linked ubiquitin chains from signaling molecules [101-123].
Xue et al., "USP10 inhibits genotoxic NF-[kappa]B activation by MCPIP1-facilitated deubiquitination of NEMO, " The EMBO Journal, vol.
G3BP associates with the 40S ribosomal subunit via its RGG motif to promote SG assembly, and the G3BP activity is modulated by Caprin and USP10, which can mutually bind to the G3BP protein [46].
SGs have antioxidant activity that is controlled by two SG components, the antioxidant enzyme USP10 and its cofactor G3BP1; G3BP1 can mask USP10 activity under steady-state conditions.
Draetta, "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease," Oncogene, vol.
Family Members USPL1, CYLD, USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP YSP8, USP9x, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17L2, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, USP46, USP47, USP48, USP49, USP50, USP51, USP52, USP53, USP54 OTUB1, OTUB2, OTUD1, OTUD3, OTUD4, OTUD5, OTUD6A, OTU OTUD6B, OTU1, HIN1L, A20, Cezanne, Cezanne2, TRABID, VCPIP1 UCH UCH-L1, UCH-L3, UCH37/UCH-L5, BAP1 Josephin ATXN3, ATXN3L, JOSD1, JOSD2 JAMM/MPN+ BRCC36, CSNS, POH1, AMSH, AMSH-LP, MPND, MYSM1, PRPF8 Table 2: Deubiquitinases and bone remodeling.
Prominently, p53 gets immediately deubiquitinylated thanks to USP10 (Ubiquitin Specific Peptidase 10) activity [73].
Positive regulation of p53 is performed due to its deubiquitination by activated USP10. Nuclear p53 tetramerization allows for transcriptional regulation of genes involved in provision of antioncogenic cellular protection.
Lou, "USP10 regulates p53 localization and stability by deubiquitinating p53," Cell, vol.