USP10A gene on chromosome 16q24.1 that encodes a widely expressed enzyme which deubiquitinates target proteins (e.g., p53/TP53), counteracting MDM2 action. In response to DNA damage, USP10 translocates to the nucleus and deubiquitinates p53/TP53, thereby regulating the p53/TP53-dependent DNA damage response. It also deubiquitinates CFTR in early endosomes, enhancing endocytic recycling, as well as BECN1, a key regulator of autophagy, leading to stabilisation of PIK3C3/VPS34-containing complexes. USP10 is specifically inhibited by spautin-1. It is also a less preferred gene symbol for what is now designated as USP32, see there.
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