Sixty-eight patients had UPJO
on the left side whereas 48 patients on the right side.
The study comprised 45 children (31 boys and 14 girls) aged 2-17 years (median = 11.0 years) with congenital unilateral HN due to UPJO
diagnosed and treated in the Department of Pediatric Nephrology, Children's University Hospital in Lublin, Poland.
Results: The results showed highly significant decrease in urinary TNF-a and caspase 3 enzyme (P values < 0.01), approaching the level measured in children without UPJO
after six months.
The patient had been followed up for his right UPJO
since birth, as he was diagnosed prenatally to have hydronephrosis.
Pyeloplasty is the gold standard management option for UPJO
and is indicated in deteriorated renal function, recurrent urinary tract infection, nephrolithiasis, pain, and concomitant hypertension .
The aim of this study is to assess the subjective symptoms and objective outcome in patients with UPJO
undergoing a laparoscopic pyeloplasty in our center.
is the most common etiology for congenital hydronephrosis.
For this purpose, we have searched for articles at PubMed and Scopus by using the combination of words: "UPJO
," "VUR," or "CAKUT" and "chemokines" or "cytokines." After this first step, we have selected the papers that evaluated cytokines as potential markers of clinical course, urinary tract obstruction, and/or CKD in pediatric patients.
Delayed imaging after the postvoid image may be required if there is VUR into a dilated renal pelvis or ureter so as to assess for concomitant UPJO
In literature, UPJO
was the most common cause of giant hydronephrosis 33% (as in our case), followed by stones 20% and congenital ureteral narrowing.
Recent international trend is toward Uretro-pelvic Junction Obstruction (UPJO
) repair with laparoscopic approach they are claiming success rate of 95%.
It should also be pointed that very few data about the role of chemokines in CAKUT were provided by clinical studies and the majority of them evaluated ureteropelvic junction obstruction (UPJO
) and vesicoureteral reflux (VUR).