MRC2

(redirected from UPARAP)
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MRC2

A gene on chromosome 17q23.2 that encodes a C-type lectin domain protein which may play a role as a lectin receptor by internalising glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. Mannose receptor C-type 2 may play roles in plasminogen activation by controlling the extracellular level of PLAUR/PLAU; in cellular uptake and remodelling, and in degradation of extracellular collagen matrices; in cancer and chronic tissue-destructive diseases acting on collagen turnover; and may participate in extracellular matrix remodelling in concert with matrix metalloproteinases.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
They have concluded that drugs that target the receptor uPARAP look very promising because this receptor is present on cancer cells in several serious cancers, and especially STS.
C-type mannose receptor 2 (MRC2, also known as ENDO180, CD280, or uPARAP) plays a supporting role in bone development being involved in collagen trafficking and deposition [53].