UPA

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UPA

Abbreviation for:
underprivileged area 
urokinase plasminogen activator

activator

(ak'ti-vat?or) [ activate]
1. A substance in the body that converts an inactive molecule into an active agent, such as the conversion of pepsinogen into pepsin by hydrogen ions.
2. Any substance that specifically induces an activity, such as an inductor or organizer in embryonic development or a trophic hormone.
3. A removable orthodontic appliance that transmits force passively from muscles to the teeth and alveolar process in contact with it. Also called myofunctional appliance.

urokinase-type plasminogen activator

Abbreviation: uPA
A protein that degrades extracellular tissues. It has been linked to the spread of some cancers by invasion and metastasis.

tissue plasminogen activator

Abbreviation: tPA, TPA
1. A natural enzyme that helps degrade blood clots by freeing plasmin from plasminogen. Plasmin in turn breaks down fibrin.
2. A recombinant enzyme, produced in the laboratory by Escherichia coli, for the treatment of thrombosis, esp. in myocardial infarction and ischemic stroke. Recombinant tPA is one of several thrombolytic drugs that can be given to patients during myocardial infarction (MI) to restore the flow of blood through occluded coronary arteries. Restoring perfusion keeps heart muscle from dying, reduces the damage caused by the infarction, and reduces the subsequent risk of congestive heart failure and death. Synonym: recombinant tPA See: thrombolysis

urokinase-type plasminogen activator

Abbreviation: uPA
A protein that degrades extracellular tissues. It has been linked to the spread of some cancers by invasion and metastasis.
See also: activator