UPA

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UPA

Abbreviation for:
underprivileged area 
urokinase plasminogen activator

activator

(ak'ti-vat?or) [ activate]
1. A substance in the body that converts an inactive molecule into an active agent, such as the conversion of pepsinogen into pepsin by hydrogen ions.
2. Any substance that specifically induces an activity, such as an inductor or organizer in embryonic development or a trophic hormone.
3. A removable orthodontic appliance that transmits force passively from muscles to the teeth and alveolar process in contact with it. Also called myofunctional appliance.

urokinase-type plasminogen activator

Abbreviation: uPA
A protein that degrades extracellular tissues. It has been linked to the spread of some cancers by invasion and metastasis.

tissue plasminogen activator

Abbreviation: tPA, TPA
1. A natural enzyme that helps degrade blood clots by freeing plasmin from plasminogen. Plasmin in turn breaks down fibrin.
2. A recombinant enzyme, produced in the laboratory by Escherichia coli, for the treatment of thrombosis, esp. in myocardial infarction and ischemic stroke. Recombinant tPA is one of several thrombolytic drugs that can be given to patients during myocardial infarction (MI) to restore the flow of blood through occluded coronary arteries. Restoring perfusion keeps heart muscle from dying, reduces the damage caused by the infarction, and reduces the subsequent risk of congestive heart failure and death. Synonym: recombinant tPA See: thrombolysis

urokinase-type plasminogen activator

Abbreviation: uPA
A protein that degrades extracellular tissues. It has been linked to the spread of some cancers by invasion and metastasis.
See also: activator
References in periodicals archive ?
uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line.
Macrophages located at the invasive front of the tumors are the cell population with the strongest contribution to the uPAR expression in GC.
A distinctive characteristic of UPARANT is that it prevents DR likely through a dual action, (i) by directly regulating its target expression and (ii) by acting at uPAR crosstalk with FPRs, influencing the activity of transcription factors regulating the expression of inflammatory markers.
Three five-minute rinses with PBS were made and the samples were incubated with the secondary antibodies: anti-rabbit IgG ALEXA Fluor 488[R] (1: 100, Abcam, Cambridge, MA, USA) for synaptopodin and anti-mouse IgG Alexa Fluor 568 (1: 100, Abcam, Cambridge, MA, USA) for uPAR in humid chamber for 2 hours at room temperature.
Professor Irfan Habib, noted historian and Professor Emeritus at the Department of History at amu, recalls that political meetings of both the Congress and the Communist Party would take place in Phool ka chauraha, a crossroads from where Upar Kot begins.
Plasma levels of uPA and its receptor uPAR are significantly increased in patients with PCa compared to healthy subjects.
Chen, "beta-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9," Melanoma Research, vol.
Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker, which is released into the circulation by cleavage of the membrane-bound uPAR from various cells, including inflammatory and endothelial cells (3).
Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand.
s in upar lose kept urn The main A90 closed both ways for a time between Stracathro and Brechin, and floodsalso shut the A85 Comrie, Perthshire,and the A92 Ardestie, Angus.
An hour later we stopped again to head off-road and up a hill for a photo shoot during which a friendly Army guy came to see "Sumo (the G55) kaise pahar-ke upar char giya"!!