UIMC1

UIMC1

A gene on chromosome 5q35.2 that encodes a ubiquitin-binding protein which plays a key role in the BRCA1-A complex by binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, targeting the BRCA1-BARD1 heterodimer to sites of double-strand breaks in DNA damage. It may indirectly downregulate transcription by inhibiting the interaction of NR6A1 with the co-repressor NCOR1. UIMC1 interacts with TSP57, ESR1, NR6A1, UBE2I and FAM175A/Abraxas; it is expressed in the testes, ovaries, thymus and heart.
References in periodicals archive ?
Cancer related (15 genes--43%) Hoxb13, Hmg20b, Cxcl16, Uimc1, Elf1, Foxp1, Ptgdr, Psmd8, Peg3, Myo15, Lig1, Ptbp2, Kif2c, Grhpr#, Fah# Enzymes (5 genes--14%) Dck, Zdhhc4, Pik3c2g, Grhpr#, Fah# Diverse functions (7 genes--20%) Adipogenesis Aamdc Nuclear Rny1, Polr1d, Nol12, Notch signaling Dtx2 Vascular remodeling Reck/St15 Ig related S72845 Unknown function (10 genes--29%) AK010802, AK007003, AK016406, AK021335, AK015506, AK009275, AK007343, AK006390, AK006570, AK005580 Bolded gene names correspond to genes that fits into two groups (because are cancer related and also enzymes).