UHRF1

A gene on chromosome 19q13.3 that encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases, which binds to specific DNA sequences and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase, and plays a major role in the G1/S transition by regulating topoisomerase II-alpha and retinoblastoma gene expression; it also functions in the p53-dependent DNA damage checkpoint.

References in periodicals archive ?

SETDB1 (SET domain, bifurcated 1) ve UHRF1 (Ubiquitin-like with PHD and rign finger domains 1) gibi gen susturulmasinda gorevli proteinlerin komplekse katilmasi ile aktive olan DNMT1 ve DNMT1o H3K9me3 isaretinin devamliligini saglamaktadir.

KAZANILMIS EPIGENETIK DEGISIKLIKLERIN KALITIMI VE HASTALIKLARA YATKINLIKTAKI ROLU/INHERITANCE OF ACQUIRED EPIGENETIC MODIFICATIONS AND ITS ROLE IN DISEASE SUSCEPTIBILITY

Additionally, the expression of UHRF1, the protein that recruits DNMT1 to hemimethylated DNA sites, was significantly reduced in a dose-dependent manner after PEP exposure.

Hypomethylation may also be mediated by decreased levels of UHRF1, which specifically interacts with DNA methyltransferases and hemimethylated sites on DNA (Ehrlich and Lacey 2013).

Effects of laser printer-emitted engineered nanoparticles on cytotoxicity, chemokine expression, reactive oxygen species, DNA methylation, and DNA damage: a comprehensive in vitro analysis in human small airway epithelial cells, macrophages, and lymphoblasts

137,138) ZFP57/KAP1 complexes also interact with DNMTs and the hemimethylated DNA binding protein UHRF1 (also called NP95), which are essential for the maintenance of DNA methylation.

2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells.

Mammalian-specific genomic functions: newly acquired traits generated by genomic imprinting and LTR retrotransposon-derived genes in mammals

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.