UHRF1

UHRF1

A gene on chromosome 19q13.3 that encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases, which binds to specific DNA sequences and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase, and plays a major role in the G1/S transition by regulating topoisomerase II-alpha and retinoblastoma gene expression; it also functions in the p53-dependent DNA damage checkpoint.
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Expanding on this idea, a review of the 5-hmC literature suggested that 5-hmC may be maintained across DNA replication via a complex of the DNMT1, Tet, and UHRF1 proteins (Shen and Zhang 2013), although the validity of this theory has not yet been determined.
Similarly, Uhrf1 (ubiquitin-like PHD ring finger-1; also known as Np95) mainly interacts with DNMT1 to maintain DNA methylation in NSCs; the deletion of Uhrf1 in NSCs leads to increase the global DNA methylation and delayed neurodegeneration [27].
Additionally, UHRF1 has been found, in murine models, to be localised within the visual system in early embryological development; however, human research is lacking [20].
Peng et al., "Promoter hypermethylation of let-7a-3 is relevant to its down-expression in diabetic nephropathy by targeting UHRF1," Gene, vol.
SETDB1 (SET domain, bifurcated 1) ve UHRF1 (Ubiquitin-like with PHD and rign finger domains 1) gibi gen susturulmasinda gorevli proteinlerin komplekse katilmasi ile aktive olan DNMT1 ve DNMT1o H3K9me3 isaretinin devamliligini saglamaktadir.
Mousli et al., "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties," Journal of Experimental & Clinical Cancer Research, vol.
Lin et al., "The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma," Molecular Carcinogenesis, vol.
To determine the significance of early epigenetic modifications on the development of neural cells during embryogenesis in the mouse, Gotz and her colleagues specifically inactivated the gene Uhrf1.
Previous studies had shown that 5hmC could interact with proteins such as the methyl-CpG-binding domain protein 3, Uhrf1, and MeCP2 and finally influence the chromatin structure and gene expression.[sup][33] Kafer et al .
(137,138) ZFP57/KAP1 complexes also interact with DNMTs and the hemimethylated DNA binding protein UHRF1 (also called NP95), which are essential for the maintenance of DNA methylation.
Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1. BiochemPharmacol, 79: 1251- 60.