In addition, the authors observed that several patients in the idiopathic NSIP group as well as in the NSIP preceding CTD diagnosis group had already fulfilled the criteria for UCTD, LD-CTD, AIF-ILD, and IPAF at the time of initial NSIP diagnosis.
In 2007, Kinder et al (10) proposed that idiopathic NSIP is a manifestation of UCTD. In this study, among 18 patients classified as UCTD who underwent surgical pulmonary biopsy, 15 showed an NSIP pattern, in contrast to only 2 patients in the control group that was categorized as idiopathic interstitial pneumonia.
A uCTD was used for measuring vertical profiles of temperature and salinity while the ship was in transit (details are in the "BoBBLE field program" section).
uCTD observations of a rain-formed low-salinity pool, (a) Salinity along a 14-km section over which 21 vertical profiles were measured just after a spell of rain.
Considering the type of rheumatic disease, the distribution of blood groups for RA, SpA, vasculitis, UCTD
, and Behcet's disease is A>O>B>AB, which appears to be the same as that in the normal population.
Patients with dcSSc had antibodies against both nuclear and nucleolar antigens in 54,5% of cases while UCTD patients had speckled antinuclear (65,2%) or antinucleolar (21.7%) responses.
The results showed that patients with SSc, either affected by lcSSc or dcSSc, have higher T cell counts and significantly lower frequencies of T reg cells (also depicted in Figure 2) as compared to UCTD patients or to healthy controls.
Herein, we describe the histopathologic features of lung involvement in 12 cases of anti-PL-12 ARS, a distinct subset of IIM, although anti-PL-12 can be seen in clinical association with other CTD or UCTD. Our study provides 2 main findings: (1) there are no pathognomonic features that would allow for a definitive diagnosis of anti-PL-12 ARS based on the histopathologic features alone, and (2) UIP is the most common form of ILD found in this autoantibody cohort.
Nonnecrotizing granulomas were seen in 3 patients: 1 patient carried a diagnosis of Sjogren syndrome, the other 2 met criteria for UCTD, including 1 with elements of rheumatoid arthritis.
Abbreviations AT: Atopic dermatitis ALBIA: Addressable laser bead assays AMR: Analytical measuring range CIA: Chemiluminescent immunoassay CLSI: Clinical and laboratory standards institute CTD: Connective tissue disease LIA: Line immunoassays MFI: Multiplex flow immunoassay PM/DM: Polymyositis/dermatomyositis RA: Rheumatoid arthritis ROC: Receiver-operating characteristics SARD: Systemic autoimmune rheumatic disease SED: Suspected eye disease SLE: Systemic lupus erythematosus SjS: Sjogren's syndrome SSc: Systemic sclerosis UCTD
: Undifferentiated connective tissue disease.
: Each vessel was also equipped with an underway thermosalinograph (UCTD
) to continuously monitor near-surface temperature and salinity from a flow-through system.
Chronic inflammation and endothelial dysfunction: analysis of a cohort of patients with SLE and UCTD