undifferentiated connective tissue disease

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undifferentiated connective tissue disease

An early stage of a connective tissue disease, in which the predominant organ of involvement or clinical form is not yet manifest. Cf Overlap syndrome, Palindromic rheumatism.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

undifferentiated connective tissue disease

,

UCTD

A connective tissue disease that does not fully meet the criteria for any of the well-defined rheumatological conditions such as rheumatoid arthritis, Sjögren's syndrome, or systemic lupus erythematosus. Signs and symptoms of connective tissue disease must be present for several years. These may include polyarticular arthritis, Raynaud's phenomenon, pleuritis, or pericarditis, among others. The patient with UCTD will also have a positive antinuclear antibody test as well as other autoantibodies. Diagnostic difficulties in UCTD may be found in people who have evidence of mixed connective tissue disease or overlap syndrome.
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In addition, the authors observed that several patients in the idiopathic NSIP group as well as in the NSIP preceding CTD diagnosis group had already fulfilled the criteria for UCTD, LD-CTD, AIF-ILD, and IPAF at the time of initial NSIP diagnosis.
In 2007, Kinder et al (10) proposed that idiopathic NSIP is a manifestation of UCTD. In this study, among 18 patients classified as UCTD who underwent surgical pulmonary biopsy, 15 showed an NSIP pattern, in contrast to only 2 patients in the control group that was categorized as idiopathic interstitial pneumonia.
A uCTD was used for measuring vertical profiles of temperature and salinity while the ship was in transit (details are in the "BoBBLE field program" section).
uCTD observations of a rain-formed low-salinity pool, (a) Salinity along a 14-km section over which 21 vertical profiles were measured just after a spell of rain.
Considering the type of rheumatic disease, the distribution of blood groups for RA, SpA, vasculitis, UCTD, and Behcet's disease is A>O>B>AB, which appears to be the same as that in the normal population.
Patients with dcSSc had antibodies against both nuclear and nucleolar antigens in 54,5% of cases while UCTD patients had speckled antinuclear (65,2%) or antinucleolar (21.7%) responses.
The results showed that patients with SSc, either affected by lcSSc or dcSSc, have higher T cell counts and significantly lower frequencies of T reg cells (also depicted in Figure 2) as compared to UCTD patients or to healthy controls.
Herein, we describe the histopathologic features of lung involvement in 12 cases of anti-PL-12 ARS, a distinct subset of IIM, although anti-PL-12 can be seen in clinical association with other CTD or UCTD. Our study provides 2 main findings: (1) there are no pathognomonic features that would allow for a definitive diagnosis of anti-PL-12 ARS based on the histopathologic features alone, and (2) UIP is the most common form of ILD found in this autoantibody cohort.
Nonnecrotizing granulomas were seen in 3 patients: 1 patient carried a diagnosis of Sjogren syndrome, the other 2 met criteria for UCTD, including 1 with elements of rheumatoid arthritis.
Abbreviations AT: Atopic dermatitis ALBIA: Addressable laser bead assays AMR: Analytical measuring range CIA: Chemiluminescent immunoassay CLSI: Clinical and laboratory standards institute CTD: Connective tissue disease LIA: Line immunoassays MFI: Multiplex flow immunoassay PM/DM: Polymyositis/dermatomyositis RA: Rheumatoid arthritis ROC: Receiver-operating characteristics SARD: Systemic autoimmune rheumatic disease SED: Suspected eye disease SLE: Systemic lupus erythematosus SjS: Sjogren's syndrome SSc: Systemic sclerosis UCTD: Undifferentiated connective tissue disease.
UCTD: Each vessel was also equipped with an underway thermosalinograph (UCTD) to continuously monitor near-surface temperature and salinity from a flow-through system.
Chronic inflammation and endothelial dysfunction: analysis of a cohort of patients with SLE and UCTD. Reumatismo.