UCP2

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UCP2

A gene on chromosome 11q13 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP2 is expressed in many tissues, especially in skeletal muscle, and thought to play a role in thermogenesis, obesity and diabetes.
References in periodicals archive ?
Millennium's UCPH patent portfolio includes four issued U.
We have leveraged our initial discovery of the UCPH gene into a very comprehensive patent estate that provides the Company with protection for compositions such as UCPH genes and proteins, as well as drug discovery methods and diagnostic methods related to UCPH.
The UCPH gene, also known as UCP2, is likely to be one of the most important genes in regulating human energy expenditure, or the 'burning of calories'," commented Robert Tepper, M.
He continued, "For more than three years, Millennium has been developing a comprehensive patent portfolio surrounding UCPH and its role in weight modulation, and we expect to receive additional patents related to this molecule in the near future.
The paper describes the expression, regulation and functional studies of UCPH as a potentially important regulator of body weight.
Millennium's international patent application describing the human gene UCPH and protein and their role in weight modulation, titled "Compositions And Methods For The Treatment of Body Weight Disorders, Including Obesity," was assigned International Publication Number WO 96/05861 and published on February 29, 1996.
The UCPH protein is a mitochondrial inner-membrane transporter
and human gene sequence of UCPH, which Millennium identified and cloned