The polymorphisms of UCP3
gene have been reported to be associated with meat quality traits in pigs.
Independent of nutritional ketosis, increased dietary fat intake increases expression of UCP2 and UCP3
in muscle , and fatty acids facilitate uncoupling through UCP2 [143, 144], UCP3
[94, 143, 144], and ANT .
Note that the loading of the item ucp3
is highly negative, because it is a reverse item.
Effects of dietary deprivation, obesity and exercise on UCP3
The rosiglitazone diet group showed a significant increase in the expression of LPL and UCP3
in liver and FAS in adipose tissue.
"Use and construction of self-referencing microelectro-chemical probes for studies into the role of Uncoupling Protein-3 (UCP3
) in myocellular energy metabolism." Dr.
Craig Warden will look for the effects of fructose on the activity of two genes, UCP2 and UCP3
. Both genes are thought to control how much energy we expend, and thus, how many calories we burn.
Briefly, UCPs are composed of five isoforms in mammals, including UCP1, UCP2, UCP3
, UCP4, and UCP5 .
H3R knockout mice exhibit an obese phenotype, suggesting that H3R regulates insulin resistance and leptin release, as well as a decrease in homeostatic energy, the cellular process for coordinating homeostatic regulation of food intake (energy inflow) and energy expenditure (energy outflow), as associated with the UCP1 and UCP3
(2009), indicated that UCPs are under direct regulation by the VD/VDR signaling, furthermore, showed that VDR overexpression in the adipose tissue led to the suppression of UCP1, UCP2, and UCP3
(Wong et al., 2011).
To validate the results of the gene chips, RT-PCR was carried out for three upregulated genes (SREBF1, DUSP1, and PLAGL1) and seven downregulated genes (FKBP5, ZBTB16, PPP1R3C, CDC14A, GLUL1, PDK4, and UCP3
Lay et al., "Sterol regulatory element binding protein-1c expression and action in rat muscles: Insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3
gene expression," Diabetes, vol.