UCP3


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UCP3

A gene on chromosome 11q13.4 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCP3 is expressed primarily in skeletal muscle, and thought to protect mitochondria against lipid-induced oxidative stress.
References in periodicals archive ?
Today, Acuo supports implementations of UCP3 around the world, including locations in Africa, Australia, Canada, New Zealand, South America, United States and the United Kingdom.
Table 2 shows the distributions of genotypes of our subjects on -866 G/A variant of UCP2 gene and -55 C/T variant of UCP3 gene.
In this study, we investigated whether capsaicin ingestion affects cardiac ANS activity and cardiac QT intervals as well as, for the first time to our knowledge, the association between cardiac ANS activity and variants of UCP2 and UCP3 polymorphisms during aerobic exercise in obese males.
Nevertheless, no studies, at least to our knowledge, are performed to investigate the alterations of cardioprotective functions upon the distribution of UCP2 and UCP3 genotypes and capsaicin supplementation during the exercise in obese individuals.
We also suggested that 866 G/A variants of UCP2, but not UCP3 polymorphism may associate with alteration of cardiac ANS activity.
Distribution of genotype defined by the -866 G/A variant of the UCP2 promoter gene and -55 C/T variant of the UCP3 promoter gene in nine obese men.
The Acuo UCP3 offering gives us the flexibility to deploy technology in a way that meets our strategic needs.
Clapham cautioned, "The precise metabolic role played by UCP3 remains unclear, and many more studies remain to be done before this line of research might result in new obesity drugs.
The direct evidence provided by this latest study for a role of UCP3 in energy consumption is consistent with indirect evidence from previous studies.
This latest study also indicated that, aside from fat combustion, UCP3 at high levels also produced other effects of interest for drug discovery: The transgenic mice exhibited 70% lower cholesterol levels than those of the controls, lower fasting glucose levels and lower insulin levels, and increased glucose clearance rates.
By modifying the gene that encodes a protein of interest, in this instance the gene encoding UCP3, researchers can better study the role of that protein in health and disease.