UCP1


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UCP1

A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.
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The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.
Orexin system increases energy expenditure by brown adipose tissue activity
Plasma irisin levels and relative mRNA expression of the genes UCP1 and FNDC5 were assessed.
Can resistance exercise alter irisin levels and expression profiles of FNDC5 and UCP1 in rats?
Cloning and ontogenetic expression of the uncoupling protein 1 gene UCP1 in sheep.
mRNA expression of ovine angiopoietin-like protein 4 gene in adipose tissues
EHMT1 increases the production of UCP1, and the deletion of this gene causes insulin resistance and obesity in mice, while haploinsufficiency is related to obesity and insulin resistance in humans [107, 108].
Biology of beige adipocyte and possible therapy for type 2 diabetes and obesity
Terzic, "Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line," Journal of Molecular and Cellular Cardiology, vol.
The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases
Brown fat UCP1 is specifically expressed in uterine longitudinal smooth muscle cells.
Exercise, uncoupling protein-3 and thermogenesis/Exercicio fisico, proteina desacopladora-3 e termogenese
Perhaps more remarkable, in vivo delivery of Irisin stimulates a robust increase in UCP1, increased energy expenditure and reversal of type II diabetes in high fat fed mice.
Sweden : Irisin - a novel myokine protective against metabolic disease
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression.
Derivation of adipocytes from human endometrial stem cells (EnSCs)
A key difference is that brown fat cells express high levels of UCP1 -- a protein required by mitochondria to burn calories and generate heat -- while beige cells normally express low levels of it.
Newly Isolated 'Beige Fat' Cells Could Help Fight Obesity
Small amounts of UCP1 can also be present in skeletal muscle which now appears to share the same common precursor cell as brown adipose tissue.
Adipostat
Sun's team found that removing the ghrelin receptor causes brown fat cells to make more of a protein called UCP1.
Mice missing protein burn more fat: research suggests molecular way to rev up body's furnace
For example, according to Nichole Deblock, director of marketing and product development, Nutraceuticals International, Elmwood Park, NJ,"Fucoxanthin from edible seaweed, Undaria pinnatifida, shows anti-obesity effects through UCP1 expression in white adipose tissues.
Marine nutraceuticals: uncharted waters? Suppliers are diving deep into the earth's oceans to find a treasure trove of health ingredients

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