UCP1


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UCP1

A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.
References in periodicals archive ?
Future studies on how PAF/PAFR signalling controls UCP1 levels through beta3-AR production in the BAT of animals and humans may reveal new therapeutic targets to treat metabolic disorders associated with obesity," Junko Sugatani, from the University of Shizuoka in Shizuoka, Japan, said.
Perhaps more remarkable, in vivo delivery of Irisin stimulates a robust increase in UCP1, increased energy expenditure and reversal of type II diabetes in high fat fed mice.
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression.
A key difference is that brown fat cells express high levels of UCP1 -- a protein required by mitochondria to burn calories and generate heat -- while beige cells normally express low levels of it.
Small amounts of UCP1 can also be present in skeletal muscle which now appears to share the same common precursor cell as brown adipose tissue.
Sun's team found that removing the ghrelin receptor causes brown fat cells to make more of a protein called UCP1.
For example, according to Nichole Deblock, director of marketing and product development, Nutraceuticals International, Elmwood Park, NJ,"Fucoxanthin from edible seaweed, Undaria pinnatifida, shows anti-obesity effects through UCP1 expression in white adipose tissues.
UCP1 ultimately results in the dissipation of heat by uncoupling oxidative respiration from the production of adenosine triphosphate, resulting in a compensatory increase in glucose metabolism by anaerobic glycolysis (1).
Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues.
UCP1 deficiency increases susceptibility to diet-induced obesity with age.
The scientific underpinning of all this is that fucoxanthin stimulates a protein called UCP1 that causes the oxidation of white adipose tissue, the harmful fat that builds up around internal organs and is associated with beerguts and "middle-aged spread".
UCP1 plays a key role in regulating energy balance in the body, and through this we can reduce body weight by increasing energy expenditure.