UCP1


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UCP1

A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.
References in periodicals archive ?
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.
Plasma irisin levels and relative mRNA expression of the genes UCP1 and FNDC5 were assessed.
Cloning and ontogenetic expression of the uncoupling protein 1 gene UCP1 in sheep.
EHMT1 increases the production of UCP1, and the deletion of this gene causes insulin resistance and obesity in mice, while haploinsufficiency is related to obesity and insulin resistance in humans [107, 108].
Terzic, "Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line," Journal of Molecular and Cellular Cardiology, vol.
Brown fat UCP1 is specifically expressed in uterine longitudinal smooth muscle cells.
Perhaps more remarkable, in vivo delivery of Irisin stimulates a robust increase in UCP1, increased energy expenditure and reversal of type II diabetes in high fat fed mice.
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression.
A key difference is that brown fat cells express high levels of UCP1 -- a protein required by mitochondria to burn calories and generate heat -- while beige cells normally express low levels of it.
Small amounts of UCP1 can also be present in skeletal muscle which now appears to share the same common precursor cell as brown adipose tissue.
Sun's team found that removing the ghrelin receptor causes brown fat cells to make more of a protein called UCP1.
For example, according to Nichole Deblock, director of marketing and product development, Nutraceuticals International, Elmwood Park, NJ,"Fucoxanthin from edible seaweed, Undaria pinnatifida, shows anti-obesity effects through UCP1 expression in white adipose tissues.