UCP1


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UCP1

A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.
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Future studies on how PAF/PAFR signalling controls UCP1 levels through beta3-AR production in the BAT of animals and humans may reveal new therapeutic targets to treat metabolic disorders associated with obesity," Junko Sugatani, from the University of Shizuoka in Shizuoka, Japan, said.
Why people tend to get fatter with age
Perhaps more remarkable, in vivo delivery of Irisin stimulates a robust increase in UCP1, increased energy expenditure and reversal of type II diabetes in high fat fed mice.
Sweden : Irisin - a novel myokine protective against metabolic disease
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression.
Derivation of adipocytes from human endometrial stem cells (EnSCs)
A key difference is that brown fat cells express high levels of UCP1 -- a protein required by mitochondria to burn calories and generate heat -- while beige cells normally express low levels of it.
Newly Isolated 'Beige Fat' Cells Could Help Fight Obesity
Small amounts of UCP1 can also be present in skeletal muscle which now appears to share the same common precursor cell as brown adipose tissue.
Adipostat
Sun's team found that removing the ghrelin receptor causes brown fat cells to make more of a protein called UCP1.
Mice missing protein burn more fat: research suggests molecular way to rev up body's furnace
For example, according to Nichole Deblock, director of marketing and product development, Nutraceuticals International, Elmwood Park, NJ,"Fucoxanthin from edible seaweed, Undaria pinnatifida, shows anti-obesity effects through UCP1 expression in white adipose tissues.
Marine nutraceuticals: uncharted waters? Suppliers are diving deep into the earth's oceans to find a treasure trove of health ingredients
UCP1 ultimately results in the dissipation of heat by uncoupling oxidative respiration from the production of adenosine triphosphate, resulting in a compensatory increase in glucose metabolism by anaerobic glycolysis (1).
Brown adipose tissue in a newborn
Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues.
Fucose complexes, fucoxanthin, fucoid, and fat storage
UCP1 deficiency increases susceptibility to diet-induced obesity with age.
Body mass and fatness of Japanese college women and relationship to place of residence
The scientific underpinning of all this is that fucoxanthin stimulates a protein called UCP1 that causes the oxidation of white adipose tissue, the harmful fat that builds up around internal organs and is associated with beerguts and "middle-aged spread".
The soup course
UCP1 plays a key role in regulating energy balance in the body, and through this we can reduce body weight by increasing energy expenditure.
CytRx-Licensed RIP 140 Research Published in Proceedings of the National Academy of Sciences

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