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UCHL1 is a specific marker identified for spermatogonial and progenitors cells, but not for differentiated spermatogonia or sertoli cells.
Gene Expression: In this study, we specifically applied UCHL1 for the identification of human germ stem cells.
Gene expression: RT-PCR was performed to confirm the expression of spermatogonial specific gene UCHL1 (ubiquitin carboxyl-terminal esterase L1; also known as protein gene product 9.
We could characterize them by the expression of a specific marker, UCHL1, that had been proved earlier as a germ stem cell marker in many species (12).
UCHL1 is a deubiquitinating enzyme that regenerates monoubiquitin from ubiquitin-protein complexes.
Of these 475 genes, UCHL1 on chromosome arm 4p was methylated in all 42 pancreatic cancers studied.
Other genes identified in precursor lesions include PENK, CDKN2A/p16, STK11/LKB1, SPARC, SFRP1/SARP2 (chromosome arm 8p), TSLC1, RELN (chromosome arm 7q), TFPI2, CLDN5 (chromosome arm 22q), and UCHL1 in IPMNs (37,122,123); PENK, CDKN2A/p16, CLDN5, NPTX2, RPRM, SFRP1/SARP2, and LHX1 (chromosome arm 11p) in PanINs (117,118,124); and CDKN2A/p16 in MCNs.
List of Selected Genes That Are Aberrantly Methylated in Pancreatic Cancer Epigenetic Chromosome Gene Gene Name Alteration Site Symbol PENK Preproenkephalin Hypermethylation 8q23-q24 UCHL1 Ubiquitin Hypermethylation 4p14 carboxylterminal esterase L1 (ubiquitin thiolesterase) MDF-1 MAD (yeast Hypermethylation 11q13 Mitosis Arrest DeFicient) related NPTX2 Neuronal Hypermethylation 7q21.
KLF3, TMEM156, WDR19, RPL9, LIAS, UGDH, UEB2K, RBM47, NSUN7, RPL7A, APBB2, UCHL1, TMEM33, SLC30A9, CCDC4, YIPF7, GABRA2 (http://www.
Leu-22 (L60): a more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
36,42,43) T-cell markers, including CD43 and UCHL1 (CD45RO), are positive.
5] The following antibodies were used: CD3, L26 (CD20), leukocyte common antigen (CD45), CD45RA, CD79a, immunoglobulin (Is) [Kappa] and [Lambda] light chains, IgC, IsM, IsA, IgD, Bcl-2, VS38c, epithelial membrane antigen (Dako, Carpinteria, Calif), Leu-22 (CD43) (Becton-Dickinson, San Jose, Calif), UCHL1 (CD45RO) (Ventana Medical Systems, Tucson, Ariz), Bc-1/cyclin D1 (P2D11Fll, Novocastra/Vector, Burlingame, Calif), syndecan-1 (CD138) (MCA681, SeroTec, Raleigh, NC), and cytokeratin (AE1/AE3) (Boehringer Mannheim, Indianapolis, Ind).
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