Long non-coding antisense RNA controls Uchl1
translation through an embedded SINEB2 repeat.
Target antigen Fluorophore Clone Company, address CD28 FITC CD28.2 CD56 FITC NCAM16.2 CD69 FITC FN50 CD94 FITC HP-3D9 CD95 FITC DX2 PD-1 FITC MIH4 PD-1 BV421 MIH4 TCR[alpha][beta] FITC T10B9.1A-31 CD8 FITC SK1 CD8 APC Cy7 SK1 BD Bioscience CD8 V500 RPA-T8 Franklin Lakes, NJ, USA CD45RO APC UCHL1
CD4 Alexa Fluor 700 RPA-T4 CD3 PE UCHT1 CD3 V450 UCHT1 CD3 BV510 UCHT1 CD19 PE HIB19 CD27 PE M-T271 CD27 BV421 M-T271 CCR7 PE-Cy7 3D12 TCR[gamma][delta] FITC IMMU510 Beckman Coulter Inc.
Li, "cPKC[gamma]-mediated down-regulation of UCHL1
alleviates ischaemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway," Journal of Cellular and Molecular Medicine, vol.
(antisense to mouse ubiquitin carboxy-terminal hydrolase L1) is a 1.2 kb lncRNA transcribed from the opposite strand of the ubiquitin carboxy-terminal hydrolase L1 (Uchl1
) gene and induces UChl1
miR-181b knockdown alleviated ischemic injury by upregulating HSPA5 and ubiquitin C-terminal hydrolase L1 (UCHL1
) expression .
This list includes ADHFE1, ALX4, CNRIP1, EID3, ELMO1, ESR1, FBN1, HLTF, LAMM, NEUROG1, NGFR, RARB, RXRG, RYR2, SDC2, SEPT9, SFRP2, SOCS3, SOX17, THBD, TMEFF2, UCHL1
, and VIM genes.
As shown in Figure 3, laminin-derived signaling induced no significant transcriptional down-regulation of octamer-binding transcription factor 4 (OCT4), homeobox transcription factor nanog (NANOG), epithelial cellular adhesion molecule (EPCAM), THY-1 T-cell antigen (THY1), or ubiquitin carboxyl-terminal esterase L1 (UCHL1
) throughout the entire culture period.
The color combination commonly used in the present study was PercP-anti-CD4 (BD Pharmingen, San Diego, CA, USA), APC-anti-CD45RO (BD Pharmingen, clone UCHL1
, San Diego, CA, USA), FITC-anti CXCR3 (R&D Systems, clone 49801, Minneapolis, MN, USA), and PE-anti CCR4 (BD Pharmingen, clone 1G1, San Diego, CA, USA).
In the current study, we chose to examine the expression of ubiquitin carboxyl-terminal esterase L1 (UCHL1
); also known as protein gene product 9.5, because it is expressed in spermatogonia of many species including bovine (2), pigs (12), mice (13), monkeys (14), etc.
The interactome/genetic overlap for significantly enriched pathways in Parkinson's disease in relation to neurotransmission was restricted to dopaminergic systems, and a number of key genes including those of the mitochondrial respiratory chain (ATP6, CYTB, and ND2), the quinone reductase NQO2, and two key Parkinson's disease genes (PINK1 and UCHL1
) figure within the enriched T.
For example, a novel deubiquinating enzyme, ubiquitin carboxyl-terminal hydrolase L1 (UCHL1
), mutated in a rare inherited form of Parkinson's disease, is normally present in vascular endothelial cells of atherosclerotic lesions of human carotid arteries and attenuates pathological vascular remodeling by inhibiting tumor necrosis factor a-induced NF-kappaB activation .
Of these 475 genes, UCHL1
on chromosome arm 4p was methylated in all 42 pancreatic cancers studied.