UCHL1

UCHL1

A gene on chromosome 4p14 that encodes a ubiquitin-protein hydrolase, involved both in processing of ubiquitin precursors and ubiquitinated proteins, which recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds free monoubiquitin and may prevent its degradation in lysosomes.
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This list includes ADHFE1, ALX4, CNRIP1, EID3, ELMO1, ESR1, FBN1, HLTF, LAMM, NEUROG1, NGFR, RARB, RXRG, RYR2, SDC2, SEPT9, SFRP2, SOCS3, SOX17, THBD, TMEFF2, UCHL1, and VIM genes.
Less studied putative CRC biomarkers, such as CNRIP1 [22], ADHFE1 [23], UCHL1, ELM01 [24], LAMA1 [25], and SOX17 [26], were also examined.
However, pSSCs experiencing collagen IV-derived signaling showed significant down-regulation of EPCAM transcription post-1 day of stimulation and UCHL1 transcription post-3 days of stimulation.
The catalytic area of UCHL1 has a loop positioned over the active site, which limits the size of ubiquitin adducts that can be processed by it to small peptides [38].
UCHL1 is a specific marker identified for spermatogonial and progenitors cells, but not for differentiated spermatogonia or sertoli cells.
Of these 475 genes, UCHL1 on chromosome arm 4p was methylated in all 42 pancreatic cancers studied.
For T cell identification a primary antibody was a CD45RO (IgG2a clone UCHL1, Termo Shadon, USA) mouse monoclonal antibody.
In their review entitled "It Is All About U(biquitin): Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease" A.
Leu-22 (L60): a more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
KLF3, TMEM156, WDR19, RPL9, LIAS, UGDH, UEB2K, RBM47, NSUN7, RPL7A, APBB2, UCHL1, TMEM33, SLC30A9, CCDC4, YIPF7, GABRA2 (http://www.
36,42,43) T-cell markers, including CD43 and UCHL1 (CD45RO), are positive.
5] The following antibodies were used: CD3, L26 (CD20), leukocyte common antigen (CD45), CD45RA, CD79a, immunoglobulin (Is) [Kappa] and [Lambda] light chains, IgC, IsM, IsA, IgD, Bcl-2, VS38c, epithelial membrane antigen (Dako, Carpinteria, Calif), Leu-22 (CD43) (Becton-Dickinson, San Jose, Calif), UCHL1 (CD45RO) (Ventana Medical Systems, Tucson, Ariz), Bc-1/cyclin D1 (P2D11Fll, Novocastra/Vector, Burlingame, Calif), syndecan-1 (CD138) (MCA681, SeroTec, Raleigh, NC), and cytokeratin (AE1/AE3) (Boehringer Mannheim, Indianapolis, Ind).