UCHL1

UCHL1

A gene on chromosome 4p14 that encodes a ubiquitin-protein hydrolase, involved both in processing of ubiquitin precursors and ubiquitinated proteins, which recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds free monoubiquitin and may prevent its degradation in lysosomes.
References in periodicals archive ?
Target antigen Fluorophore Clone Company, address CD28 FITC CD28.2 CD56 FITC NCAM16.2 CD69 FITC FN50 CD94 FITC HP-3D9 CD95 FITC DX2 PD-1 FITC MIH4 PD-1 BV421 MIH4 TCR[alpha][beta] FITC T10B9.1A-31 CD8 FITC SK1 CD8 APC Cy7 SK1 BD Bioscience CD8 V500 RPA-T8 Franklin Lakes, NJ, USA CD45RO APC UCHL1 CD4 Alexa Fluor 700 RPA-T4 CD3 PE UCHT1 CD3 V450 UCHT1 CD3 BV510 UCHT1 CD19 PE HIB19 CD27 PE M-T271 CD27 BV421 M-T271 CCR7 PE-Cy7 3D12 TCR[gamma][delta] FITC IMMU510 Beckman Coulter Inc.
Li, "cPKC[gamma]-mediated down-regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway," Journal of Cellular and Molecular Medicine, vol.
AS Uchl1 (antisense to mouse ubiquitin carboxy-terminal hydrolase L1) is a 1.2 kb lncRNA transcribed from the opposite strand of the ubiquitin carboxy-terminal hydrolase L1 (Uchl1) gene and induces UChl1 translation.
miR-181b knockdown alleviated ischemic injury by upregulating HSPA5 and ubiquitin C-terminal hydrolase L1 (UCHL1) expression [29].
This list includes ADHFE1, ALX4, CNRIP1, EID3, ELMO1, ESR1, FBN1, HLTF, LAMM, NEUROG1, NGFR, RARB, RXRG, RYR2, SDC2, SEPT9, SFRP2, SOCS3, SOX17, THBD, TMEFF2, UCHL1, and VIM genes.
As shown in Figure 3, laminin-derived signaling induced no significant transcriptional down-regulation of octamer-binding transcription factor 4 (OCT4), homeobox transcription factor nanog (NANOG), epithelial cellular adhesion molecule (EPCAM), THY-1 T-cell antigen (THY1), or ubiquitin carboxyl-terminal esterase L1 (UCHL1) throughout the entire culture period.
The color combination commonly used in the present study was PercP-anti-CD4 (BD Pharmingen, San Diego, CA, USA), APC-anti-CD45RO (BD Pharmingen, clone UCHL1, San Diego, CA, USA), FITC-anti CXCR3 (R&D Systems, clone 49801, Minneapolis, MN, USA), and PE-anti CCR4 (BD Pharmingen, clone 1G1, San Diego, CA, USA).
In the current study, we chose to examine the expression of ubiquitin carboxyl-terminal esterase L1 (UCHL1); also known as protein gene product 9.5, because it is expressed in spermatogonia of many species including bovine (2), pigs (12), mice (13), monkeys (14), etc.
The interactome/genetic overlap for significantly enriched pathways in Parkinson's disease in relation to neurotransmission was restricted to dopaminergic systems, and a number of key genes including those of the mitochondrial respiratory chain (ATP6, CYTB, and ND2), the quinone reductase NQO2, and two key Parkinson's disease genes (PINK1 and UCHL1) figure within the enriched T.
For example, a novel deubiquinating enzyme, ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), mutated in a rare inherited form of Parkinson's disease, is normally present in vascular endothelial cells of atherosclerotic lesions of human carotid arteries and attenuates pathological vascular remodeling by inhibiting tumor necrosis factor a-induced NF-kappaB activation [85].
Of these 475 genes, UCHL1 on chromosome arm 4p was methylated in all 42 pancreatic cancers studied.