USP18

(redirected from UBP43)

USP18

A gene on chromosome 22q11.21 that encodes a C19 ubiquitin-specific peptidase which only efficiently cleaves ISG15 fusions. It is required for maintaining a critical intracellular balance of ISG15-conjugated proteins in normal and stressed organisms.
References in periodicals archive ?
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.
The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.
J., Zhang, D.E., 2007.Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp 18) deficient macrophages.