UBE2C

UBE2C

A gene on chromosome 20q13.12 that encodes a member of the E2 ubiquitin-conjugating enzyme family required for post-replicative DNA damage repair. UBE2C is required for the destruction of mitotic cyclins and for cell cycle progression.
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The resulting analysis identified 18 genes - some such as AURKA, UBE2C, TPX2, FAM83D, ZNF217, SALL4 and MMP9 have been previously known to potentially cause cancer.
The connectivity degree of certain genes exceeded 20, including DHX15, NDUFS3, PSMC6, UBE2C, EIF4G1, DHX9, PSMC3, and HNRNPA2B1 in the upregulated PPI network, and MAPK1, IL6, FN1, MAPK14, STAT3, and VWF in the downregulated PPI network (Table 1).
Two of the E2 enzymes with a role in cancer are UbcH10 (also known as UBE2C or UBC4) and UBE2S (also called E2-EPF), both of which work with E3 ligase APC/C (Anaphase Promoting Complex/Cyclosome) in the regulation of the cell cycle.
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
In the recent reclassification of breast cancers on the basis of copy number expression analysis, the 5q loss is associated with a strong basal-specific signature, including aurora kinase B (AURKB), B-cell CLL/lymphoma 2 (BCL2), BUB1 mitotic checkpoint serine/threonine kinase (BUB1), cell division cycle associated 3 (CDCA3), cell division cycle associated 4 (CDCA4), cell division cycle 20 (CDC20), cell division cycle 45 (CDC45), checkpoint kinase 1 (CHEK1), forkhead box M1 (FOXM1), histone deacetylase 2 (HDAC2), insulin-like growth factor 1 receptor (IGF1R), kinesin family member 2C (KIF2C), kinesin family member C1 (KIFC1), methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L), TTK protein kinase (TTK), and ubiquitin-conjugating enzyme E2C (UBE2C).
Malmstrom, "Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer," The American Journal of Pathology, vol.
During PCa progression, many androgen-regulated genes including UBE2C, CND1, p21, and p27 are up-regulated [43, 44].
Ube2c, Ccnb2, Cdc2a, and Aurkb are all associated with the G2/M phases of the cell cycle, and are also all increased in the WT uterus by [E.sub.2] after 24 hr.
The qPCR primers and hydrolysis probes for the genes CALM2 [calmodulin 2 (phosphorylase kinase, delta)], CHPT1 (choline phosphotransferase 1), CXCL13 [chemokine (C-X-Cmotif) ligand 13], ERBB2 [v-erbb2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)], ESR1 (estrogen receptor 1), IGKC (immunoglobulin kappa constant), MLPH (melanophilin), MMP1 [matrix metallopeptidase 1 (interstitial collagenase)], OAZ1 (ornithine decarboxylase antizyme 1), PGR (progesterone receptor), RAC-GAP1 (Rac GTPase activating protein 1), RPL37A, TOP2A [topoisomerase (DNA) II alpha 170kDa], and UBE2C (ubiquitin-conjugating enzyme E2C) were identified with Primer Express[TM] software (Applied Biosystems) according to the manufacturer's instructions.
(a) Probe Gene Fold- Unigene ID set ID Gene title symbol change P[53.sup.(+)] cells 520028 31692_at heat shock 70kDA protein 1A HSPA1A 4.7 419 34585_at distal-less homeo box 2 DLX2 2.3 171695 1005_at dual specificity phosphatase 1 DUSP1 2.1 (MKP-1) P[53.sup.(-)] cells 142912 36799_at frizzled homolog 2 (Drosophila) FZD2 4.2 50308 40121_at huntingtin interacting protein HIP2 2.5 2 93002 1651_at ubiquitin-conjugating enzyme UBE2C 2.2 E2C 524630 36604_at ubiquitin-conjugating enzyme UBE2N 2.2 E2N (a) Gene annotations from NetAffx (http://www.affymetrix.com/analysis/index.affx).