UBE2A

UBE2A

A gene on chromosome Xq24 that encodes a member of the E2 ubiquitin-conjugating enzyme family required for post-replicative repair of UV-damaged DNA.
References in periodicals archive ?
CDK9's role in promoting genome integrity is regulated at least in part through deacetylation by the SIRT2 sirtuin deacetylase and breast tumor suppressor protein, which promotes its kinase activity [11] and in turn phosphorylates UBE2A and directs H2Bub1 and PCNA ubiquitinylation [12].
Lukiw, "Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer's disease (AD) is linked to deficits in a natural circular miRNA-7 sponge (circRNA; ciRS-7)," Genes, vol.
The gene for BDCS has been mapped to the distal part of the long arm of chromosome X, in the Xq24-q27.1 region.3 A culprit gene has been proposed, the UBE2A gene, thought to be involved in DNA repair after ultraviolet-induced damage, and which has been mapped to Xq24-q25.3 A large number of families with BDCS originated from Central Europe, mostly from Belgium and France.
A number of these genes play a role in mediating DNA repair, including ubiquitin-conjugating enzyme E2A (UBE2A), which is a member of the RAD6 pathway that uses ubiquitin conjugation to control DNA damage-induced mutagenesis (Stelter and Ulrich 2003).