UBE2C

(redirected from UBCH10)

UBE2C

A gene on chromosome 20q13.12 that encodes a member of the E2 ubiquitin-conjugating enzyme family required for post-replicative DNA damage repair. UBE2C is required for the destruction of mitotic cyclins and for cell cycle progression.
References in periodicals archive ?
Although expression of single genes, such as HMGA2 and UbcH10, has been evaluated to determine the potential to separate benign from malignant tumors in thyroid FNA aspirates, the application of GEA has been limited by low sensitivity and specificity.
Two of the E2 enzymes with a role in cancer are UbcH10 (also known as UBE2C or UBC4) and UBE2S (also called E2-EPF), both of which work with E3 ligase APC/C (Anaphase Promoting Complex/Cyclosome) in the regulation of the cell cycle.